July 30, 2016
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Demerol

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Demerol




Indications
Dosage
How Supplied

INDICATIONS

For the relief of moderate to severe pain

For preoperative medication

For support of anesthesia

For obstetrical analgesia

DOSAGE AND ADMINISTRATION

For Relief Of Pain

Dosage should be adjusted according to the severity of the pain and the response of the patient. While subcutaneous administration is suitable for occasional use, intramuscular administration is preferred when repeated doses are required. If intravenous administration is required, dosage should be decreased and the injection made very slowly, preferably utilizing a diluted solution. The dose of Demerol™ should be proportionately reduced (usually by 25 to 50 percent) when administered concomitantly with phenothiazines and many other tranquilizers since they potentiate the action of Demerol™.

Adults

The usual dosage is 50 mg to 150 mg intramuscularly or subcutaneously every 3 or 4 hours as necessary. Elderly patients should usually be given meperidine at the lower end of the dose range and observed closely.

Children

The usual dosage is 0.5 mg/lb to 0.8 mg/lb intramuscularly or subcutaneously up to the adult dose, every 3 or 4 hours as necessary.

For Preoperative Medication

Adults

The usual dosage is 50 mg to 100 mg intramuscularly or subcutaneously, 30 to 90 minutes before the beginning of anesthesia. Elderly patients should usually be given meperidine at the lower end of the dose range and observed closely.

Children

The usual dosage is 0.5 mg/lb to 1 mg/lb intramuscularly or subcutaneously up to the adult dose, 30 to 90 minutes before the beginning of anesthesia.

For Support Of Anesthesia

Repeated slow intravenous injections of fractional doses (e.g., 10 mg/mL) or continuous intravenous infusion of a more dilute solution (e.g., 1 mg/mL) should be used. The dose should be titrated to the needs of the patient and will depend on the premedication and type of anesthesia being employed, the characteristics of the particular patient, and the nature and duration of the operative procedure. Elderly patients should usually be given meperidine at the lower end of the dose range and observed closely.

For Obstetrical Analgesia

The usual dosage is 50 mg to 100 mg intramuscularly or subcutaneously when pain becomes regular, and may be repeated at 1- to 3-hour intervals.

Parenteral drug products should be inspected visually for particulate and discoloration prior to administration whenever solution and container permit.

HOW SUPPLIED

For Parenteral Use

Solutions of Demerol™ for parenteral use are clear and colorless and are available as follows:

Unit of Sale Concentration (per total volume) Each
NDC 0409-1203-01
Box of 25
25 mg/0.5 mL NDC 0409-1203-11
0.5 mL fill in 1 mL Single-use Uni-Amp™
NDC 0409-1253-01
Box of 25
50 mg/mL NDC 0409-1253-11
1 mL fill in 1 mL Single-use Uni-Amp™
NDC 0409-1254-01
Box of 25
75 mg/1.5 mL (50 mg/mL) NDC 0409-1254-11
1.5 mL fill in 2 mL Single-use Uni-Amp™
NDC 0409-1255-02
Box of 25
100 mg/2 mL (50 mg/mL) NDC 0409-1255-12
2 mL fill in 2 mL Single-use Uni-Amp™
NDC 0409-1256-01
Box of 25
100 mg/mL NDC 0409-1256-11
1 mL fill in 1 mL Single-use Uni-Amp™
NDC 0409-1181-30
Box of 1
1500 mg/30 mL (50 mg/mL) NDC 0409-1181-30
30 mL fill in 30 mL Multiple-use Vial
NDC 0409-1201-20
Box of 1
2000 mg/20 mL (100 mg/mL) NDC 0409-1201-20
20 mL fill in 20 mL Multiple-use Vial
NDC 0409-1176-30
Box of 10
25 mg/mL NDC 0409-1176-03
1 mL fill in 2.5 mL Carpuject™ Single-use cartridge with Luer Lock for the Carpuject™ Syringe System
NDC 0409-1178-30
Box of 10
50 mg/mL NDC 0409-1178-03
1 mL fill in 2.5 mL Carpuject™ Single-use cartridge with Luer Lock for the Carpuject™ Syringe System
NDC 0409-1179-30
Box of 10
75 mg/mL NDC 0409-1179-03
1 mL fill in 2.5 mL Carpuject™ Single-use cartridge with Luer Lock for the Carpuject™ Syringe System
NDC 0409-1180-69
Box of 10
100 mg/mL NDC 0409-1180-59
1 mL fill in 2.5 mL Carpuject™ Single-use cartridge with Luer Lock for the Carpuject™ Syringe System

Carpuject™ Single-use cartridges with Luer Lock are packaged in a Slim-Pak™ tamper detection package. Note that a needle is not included.

Instructions For Use Of The Syringe Systems

Instructions for using the Carpuject™ Syringe are available with the reusable Carpuject™ Holder, List 2049-02.

Carpuject™ Single-use cartridges are to be used ONLY with Carpuject™ Holders, List 2049-02.

To prevent needle-stick injuries, needles should not be recapped, purposely bent, or broken by hand. Blunt cannulas should not be recapped, purposely bent or broken by hand.

NOTE: The pH of Demerol™ solutions is adjusted between 3.5 and 6 with sodium hydroxide or hydrochloric acid. Multiple-use vials contain metacresol 0.1 percent as preservative. No preservatives are added to the ampuls or Carpuject™ sterile cartridge units.

Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.]

Hospira, Inc., Lake Forest, IL 60045 USA. Revised: Nov 2015

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 1/5/2016

Indications
Dosage
How Supplied

Demerol - User Reviews

Demerol User Reviews

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