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Demser

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IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

METYROSINE - ORAL

(me-TYE-roe-seen)

COMMON BRAND NAME(S): Demser

USES: This medication is used to treat high blood pressure in people with a certain adrenal gland tumor (pheochromocytoma). Metyrosine is used to prevent high blood pressure before and immediately after surgery to remove the tumor. It is also used long-term in people who cannot have the surgery. It is not used for other kinds of high blood pressure.

Metyrosine prevents the tumor from making certain natural substances (catecholamines) that raise the blood pressure and make the heart beat faster. Lowering the amount of catecholamines lessens the risk of a very serious attack of high blood pressure (hypertensive crisis).

HOW TO USE: Take this medication by mouth with or without food, usually 4 times a day or as directed by your doctor. The dosage is based on your medical condition and response to treatment. Do not take more than a total of 4 grams each day.

Your doctor may direct you to start taking this drug at a low dose and slowly increase your dose until you are taking the best dose for you. Your doctor will check your blood pressure and order lab tests (e.g., urine tests for catecholamines) to find the best dose.

During treatment with this medication, it is important that you get plenty of fluids and pass urine frequently to help avoid kidney and bladder side effects. Ask your doctor how much fluid you should drink and how often you should urinate each day, and follow these instructions carefully.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Do not stop taking this medication without consulting your doctor. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick. You may have trouble sleeping (insomnia) for 2 to 3 days after you stop taking this medication. Tell your doctor if these symptoms persist or worsen or if you have other symptoms of very high blood pressure (e.g., headache, nausea, sweating, fast heartbeat).

This medication is usually taken for at least 5 to 7 days before surgery.

Tell your doctor if your condition does not improve or if it worsens (e.g., headache, nausea, sweating, fast heartbeat, high blood pressure readings).

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