"Scientists at the National Institutes of Health report they have discovered in mouse studies that a small molecule released in the spinal cord triggers a process that is later experienced in the brain as the sensation of itch.
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Details with Side Effects
DENAVIR is a prescription topical cream for the treatment of cold sores (recurrent herpes labialis) that occur on the face and lips. It is not a cure for cold sores and not all patients respond to it. Do not use if you are allergic to DENAVIR (penciclovir) or any of the ingredients in DENAVIR. Before you use DENAVIR, tell your doctor if you are pregnant, planning to become pregnant, or are breast-feeding.
Instructions for Use
Wash your hands. Your face should be clean and dry. Apply a layer of DENAVIR to cover only the cold sore area or the area of tingling (or other symptoms) before the cold sore appears. Rub in the cream until it disappears. Apply the cream every 2 hours during waking hours for 4 days. Treatment should be started at the earliest sign of a cold sore (i.e. tingling, redness, itching, or bump). Wash your hands with soap and water after using DENAVIR. Store DENAVIR at room temperature between 68°F to 77°F (20°C to 25°C). Keep out of reach of children.
Possible Side Effects
DENAVIR was well tolerated in clinical studies in patients with cold sores. Common skin-related side effects that occurred when DENAVIR was applied are application site reactions, local anesthesia, and rash. Taste perversion was also reported.
Last reviewed on RxList: 9/25/2013
This monograph has been modified to include the generic and brand name in many instances.
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