May 30, 2016


Depakote Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP


Last reviewed on RxList 1/29/2016

Depakote (divalproex sodium) is a stable coordination compound comprised of sodium valproate and valproic acid used to treat manic episodes associated with bipolar disorder, epilepsy, and migraine headaches. Generic Depakote (termed divalproex sodium) is available under several other names. Side effects of Depakote include drowsiness, weakness, nausea, vomiting, stomach upset, diarrhea, constipation, mood swings, changes in menstrual periods, enlarged breasts, weight changes, agitation, tremor (shaking), vision changes, unusual or unpleasant taste in your mouth, and hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Depakote FDA Prescribing Information: Side Effects
(Adverse Reactions)

Read the entire FDA prescribing information for Depakote (Depakote Divalproex Sodium Tablets)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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