Depakote Sprinkle Capsules (Divalproex Sodium Sprinkle Capsules) Drug Information: Overdosage and Contraindications

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May 27, 2012

Depakote Sprinkle Capsules

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Migraine medications overview

Migraine is a serious, potentially life-threatening neurological disease that affects nearly 32 million Americans, the majority of whom are women. The hallmark symptom of migraine is an escalating, often unbearable, debilitating headache that is commonly described as intense throbbing or pulsating pain in one area of the head. The pain may be accompanied by extreme sensitivity to light and sound, nausea, and vomiting. In some people, migraines are preceded by visual disturbances known as auras that may include flashing lights, zigzag lines, or temporary blindness.

Migraine medications do not cure migraines. Instead, migraine drugs treat the symptoms using one of two approaches. Some migraine drugs relieve symptoms. Other migraine drugs are used to prevent a migraine attack.

Many migraine sufferers rely on simple pain relievers to get through an attack. These range from over-the-counter analgesics like acetaminophen to an...

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Depakote Sprinkle Capsules

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OVERDOSE

Over dosage with valproate may result in somnolence, heart block, and deep coma. Fatalities have been reported; however patients have recovered from valproate levels as high as 2120 mcg/mL.

In overdose situations, the fraction of drug not bound to protein is high and hemodialysis or tandem hemodialysis plus hemoperfusion may result in significant removal of drug. The benefit of gastric lavage or emesis will vary with the time since ingestion. General supportive measures should be applied with particular attention to the maintenance of adequate urinary output.

Naloxone has been reported to reverse the CNS depressant effects of valproate over dosage. Because naloxone could theoretically also reverse the antiepileptic effects of valproate, it should be used with caution in patients with epilepsy.

CONTRAINDICATIONS

Depakote Sprinkle Capsules (divalproex sodium sprinkle capsules) should not be administered to patients with hepatic disease or significant hepatic dysfunction [see WARNINGS and PRECAUTIONS].
Depakote Sprinkle Capsules (divalproex sodium sprinkle capsules) is contraindicated in patients with known hypersensitivity to the drug [see WARNINGS and PRECAUTIONS].
Depakote Sprinkle Capsules (divalproex sodium sprinkle capsules) is contraindicated in patients with known urea cycle disorders [see WARNINGS and PRECAUTIONS].