"Oct. 18, 2012 -- While the use of long-acting intrauterine devices (IUDs) is increasing, 1 in 9 women at risk for unintended pregnancies is not using any birth control, according to a new government report.
Researchers from the Natio"...
(medroxyprogesterone acetate) Injectable Suspension, USP
DEPO-PROVERA Sterile Aqueous Suspension contains medroxyprogesterone acetate, which is a derivative of progesterone and is active by the parenteral and oral routes of administration. It is a white to off-white, odorless crystalline powder, stable in air, melting between 200° and 210° C. It is freely soluble in chloroform, soluble in acetone and in dioxane, sparingly soluble in alcohol and methanol, slightly soluble in ether and insoluble in water.
The chemical name for medroxyprogesterone acetate is Pregn-4-ene-3, 20-dione, 17(acetyloxy)-6-methyl-, (6α)-. The structural formula is:
DEPO-PROVERA for intramuscular injection is available as 400 mg/mL medroxyprogesterone acetate. Each mL of the 400 mg/mL suspension contains:
Medroxyprogesterone acetate .............400 mg
Polyethylene glycol 3350....................20.3 mg
Sodium sulfate anhydrous .....................11 mg
Myristyl-gamma-picolinium chloride ............................................1.69 mg added as preservative
When necessary, pH was adjusted with sodium hydroxide and/or hydrochloric acid.
What are the possible side effects of medroxyprogesterone (Depo-Provera, Depo-Provera Contraceptive, Depo-SubQ Provera 104)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- menstrual periods that are heavier or longer than normal;
- sudden numbness or weakness, especially on one side of the body;
- sudden severe headache, confusion, problems with vision, speech, or balance;
- chest pain, sudden cough, wheezing, rapid breathing,...
What are the precautions when taking medroxyprogesterone (Depo-Provera)?
Before using medroxyprogesterone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood clots (for example, in the legs, eyes, lungs), unexplained vaginal bleeding, asthma, abnormal breast exam, personal or family history of cancer (especially breast or cervical cancer), daily use of alcohol/tobacco, depression, diabetes, eating disorder (anorexia), heart problems (such as heart failure, irregular heartbeat, previous heart attack), high blood pressure, kidney disease, liver disease (including...
Last reviewed on RxList: 6/28/2016
This monograph has been modified to include the generic and brand name in many instances.
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