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Depo-Provera Patient Information including How Should I Take

What should I discuss with my healthcare provider before using medroxyprogesterone (Depo-Provera)?

This medication may cause bone loss (osteoporosis) especially when used over long periods of time. Bone loss may not be reversible. Do not use this medication for longer than 2 years. Talk with your doctor about your specific risk of bone loss.

Medroxyprogesterone can cause birth defects. Do not use if this medication if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Also tell your doctor if you plan to become pregnant soon after you stop using medroxyprogesterone.

You should not use this medication if you are allergic to medroxyprogesterone, or if you have:

  • unusual vaginal bleeding;
  • liver disease;
  • a history of breast cancer; or
  • a history of heart attack, stroke, or blood clot.

To make sure you can safely use medroxyprogesterone, tell your doctor if you have any of these other conditions:

  • kidney disease;
  • high blood pressure, congestive heart failure;
  • migraine headaches;
  • a personal or family history of diabetes;
  • asthma;
  • bone disease or a family history of osteoporosis;
  • seizures;
  • depression, or an eating disorder;
  • light, heavy, or irregular menstrual periods;
  • a family history of breast cancer;
  • if you have ever had a breast lump, an abnormal mammogram, or bleeding from your nipples; or
  • if you drink large amounts of alcohol or if you smoke.

Medroxyprogesterone passes into breast milk, but it is not known whether this could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use medroxyprogesterone (Depo-Provera)?

Medroxyprogesterone is injected into a muscle or under the skin. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

Medroxyprogesterone may be given once per week or once every 3 months, depending on why you are using the medication. Follow your doctor's instructions.

Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

You may have breakthrough bleeding while using medroxyprogesterone. Tell your doctor if this bleeding continues or is very heavy.

This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using medroxyprogesterone.

Your doctor will need to see you on a regular basis while you are using this medication. Do not miss any appointments.

Store at room temperature away from moisture and heat.

Side Effects Centers

Depo Provera - User Reviews

Depo Provera User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Depo Provera sorted by most helpful. Patient Discussions FAQs

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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