August 30, 2015
Recommended Topic Related To:

Depo-Provera

"Nov. 26, 2012 -- Pediatricians should routinely talk to their teen patients about emergency birth control and write them prescriptions for “morning-after pills” so they can get them quickly if necessary, according to a new policy statement from t"...

Depo-Provera




Depo-Provera Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 4/17/2015

Depo-Provera CI (medroxyprogesterone acetate) is a form of progesterone, a female hormone used as contraception to prevent pregnancy. It is also used to reduce pain cause by endometriosis, and to ease pain and symptoms in women with metastatic uterine or kidney cancer. Depo-Provera CI is available in generic form. Common side effects of Depo-Provera CI include changes in menstrual periods, weight gain, nausea, stomach cramping/bloating, dizziness, headache, tiredness, irritability, breast tenderness, decrease in breast size, acne, hair loss, decreased sex drive, hot flashes, joint pain, or irritation/pain/skin changes at injection site.

The recommended dose of Depo-Provera is 150 mg every 13 weeks administered by deep intramuscular (IM) injection in the gluteal or deltoid muscle. Depo-Provera CI should not be used as a long-term birth control method (longer than 2 years). Depo-Provera may interact with aminoglutethimide (Cytadren). Other drugs may interact with Depo-Provera. Tell your doctor all prescription and over-the-counter medications and supplements you use. Depo-Provera must not be used during pregnancy. It may take longer for you to get pregnant after you stop using this medication. This drug passes into breast milk. Consult your doctor before breast-feeding.

Our Depo-Provera CI (medroxyprogesterone acetate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Depo-Provera in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • menstrual periods that are heavier or longer than normal;
  • sudden numbness or weakness, especially on one side of the body;
  • sudden severe headache, confusion, problems with vision, speech, or balance;
  • chest pain, sudden cough, wheezing, rapid breathing, coughing up blood;
  • pain, swelling, warmth, or redness in one or both legs;
  • fever;
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • swelling in your hands, ankles, or feet; or
  • symptoms of depression (sleep problems, weakness, mood changes).

Less serious side effects may include:

  • changes in your menstrual periods;
  • weight gain;
  • mild headache, drowsiness;
  • mild stomach pain;
  • hot flashes;
  • joint pain;
  • breast tenderness;
  • feeling tired or irritable;
  • acne;
  • decreased sex drive; or
  • skin changes or a hard lump where the injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Depo-Provera (Medroxyprogesterone)

What is Patient Information Overview?

A concise overview of the drug for the patient or caregiver from First DataBank.

Depo-Provera Overview - Patient Information: Side Effects

SIDE EFFECTS: Nausea, bloating, headache, changes in appetite, weight gain, tiredness, swelling, acne, hot flashes, breast tenderness, or irritation/pain at the injection site may occur. Vaginal bleeding between periods (spotting) or missed/irregular periods may occur, especially during the first few months of use. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Your periods may stop completely after you have been receiving this medication for about a year. If this occurs, your periods will normally return after you stop using this medication. If you miss a period and have missed an injection, or if more than 13 weeks pass between injections and you think you might be pregnant, contact your doctor for a pregnancy test.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as new/worsening depression), changes in sexual interest/ability, swelling of the ankles/feet, bone pain, unusual changes in vaginal bleeding (such as continuous spotting, sudden heavy bleeding), persistent nausea/vomiting, severe stomach/abdominal/pelvic pain, unusual weakness/tiredness, dark urine, yellowing eyes/skin, seizure.

This medication may increase your risk of breast cancer. Tell your doctor right away if you have symptoms such as a lump in the breast, nipple discharge. Ask your doctor for more details.

This medication may rarely cause serious (sometimes fatal) problems from blood clots (such as deep vein thrombosis, heart attack, pulmonary embolism, stroke). Get medical help right away if you have: shortness of breath/rapid breathing, chest/jaw/left arm pain, unusual sweating, confusion, sudden dizziness/fainting, pain/swelling/warmth in the groin/calf, sudden/severe headaches, slurred speech, weakness on one side of the body, sudden vision changes.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Depo-Provera (Medroxyprogesterone)

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Depo-Provera FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

See PRECAUTIONS for possible adverse effects on the fetus

Reproductive System and Breast Disorders

Nervous System Disorders

Psychiatric Disorders

  • nervousness
  • euphoria
  • mental depression
  • insomnia

General Disorders and Administration Site Conditions

Investigations

  • change in weight (increase or decrease)

Hepatobiliary Disorders

Skin and Subcutaneous Tissue Disorders

Immune System Disorders

Gastrointestinal Disorders

  • nausea

Endocrine Disorders

  • corticoid-like effects (e.g., Cushingoid syndrome)

Metabolism and Nutrition Disorders

In a few instances there have been undesirable sequelae at the site of injection, such as residual lump, change in color of skin, or sterile abscess.

A statistically significant association has been demonstrated between use of estrogen-progestin combination drugs and pulmonary embolism and cerebral thrombosis and embolism. For this reason patients on progestin therapy should be carefully observed. There is also evidence suggestive of an association with neuro-ocular lesions, e.g. retinal thrombosis and optic neuritis.

The following adverse reactions have been observed in patients receiving estrogenprogestin combination drugs:

The following laboratory results may be altered by the use of estrogen-progestin combination drugs:

  • increased sulfobromophthalein retention and other hepatic function tests
  • coagulation tests: increase in prothrombin factors VII, VIII, IX, and X
  • metyrapone test
  • pregnanediol determinations
  • thyroid function: increase in PBI, and butanol extractable protein bound iodine and decrease in T3 uptake values

Read the entire FDA prescribing information for Depo-Provera (Medroxyprogesterone)

Depo Provera - User Reviews

Depo Provera User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Depo Provera sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Women's Health

Find out what women really need.