"The US Food and Drug Administration (FDA) is ordering stricter warnings and contraindications for the anemia drug ferumoxytol (Ferumoxytol, AMAG Pharmaceuticals), stating that even with current warnings, there have been 79 anaphylactic r"...
(deferoxamine mesylate) for Injection
Desferal, deferoxamine mesylate USP, is an iron-chelating agent, available in vials for intramuscular, subcutaneous, and intravenous administration. Desferal is supplied as vials containing 500 mg and 2 g of deferoxamine mesylate USP in sterile, lyophilized form. Deferoxamine mesylate is N-[5-[3-[(5aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(Nhydroxyacetamido)pentyl]carbamoyl]propionohydroxamic acid monomethanesul-fonate (salt), and its structural formula is
Deferoxamine mesylate USP is a white to off-white powder. It is freely soluble in water and slightly soluble in methanol. Its molecular weight is 656.79.
What are the possible side effects of deferoxamine (Desferal)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; joint or muscle pain; fever; headache; nausea or vomiting; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using deferoxamine and call your doctor at once if you have any of these serious side effects:
- cough, wheezing, gasping, or other breathing problems;
- urinating less than usual or not at all;
- drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting;
- swelling, weight gain, feeling short...
What are the precautions when taking deferoxamine (Desferal)?
Before using deferoxamine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, rheumatoid arthritis, diabetes, any fungal infection.
If you are using this medication for aluminum poisoning, also tell your doctor or pharmacist if you have: seizures, decreased calcium levels in the blood, hyperparathyroidism.
This drug may make you dizzy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you...
Last reviewed on RxList: 2/13/2017
This monograph has been modified to include the generic and brand name in many instances.
Additional Desferal Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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