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Animal Oral LD50
The oral LD50 of the drug is 610 mg/kg in mice, 486 mg/kg in rats, and 560 mg/kg in rabbits.
Signs and Symptoms
Death from overdose has occurred in patients ingesting DESYREL (trazodone hydrochloride) and other drugs concurrently (namely, alcohol; alcohol + chloral hydrate + diazepam; amobarbital; chlordiazepoxide; or meprobamate).
The most severe reactions reported to have occurred with overdose of DESYREL (trazodone hydrochloride) alone have been priapism, respiratory arrest, seizures, and EKG changes. The reactions reported most frequently have been drowsiness and vomiting. Overdosage may cause an increase in incidence or severity of any of the reported adverse reactions (see ADVERSE REACTIONS).
There is no specific antidote for DESYREL (trazodone hydrochloride) . Treatment should be symptomatic and supportive in the case of hypotension or excessive sedation. Any patient suspected of having taken an overdose should have the stomach emptied by gastric lavage. Forced diuresis may be useful in facilitating elimination of the drug.
DESYREL (trazodone hydrochloride) is contraindicated in patients hypersensitive to DESYREL (trazodone hydrochloride) .
Last reviewed on RxList: 4/13/2011
This monograph has been modified to include the generic and brand name in many instances.
Additional Desyrel Information
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