Detrol (Tolterodine Tartrate) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 3, 2012

Detrol

Urinary Incontinence »

Urinary incontinence (UI) in men facts

*Urinary incontinence (UI) in men facts Medically Edited by: Melissa Conrad Stöppler, MD

The definition of urinary incontinence in men is the unintentional loss of urine. Weak bladder muscles, overactive bladder muscles, certain prostate conditions, and nerve damage are just some of the possible underlying causes of urinary incontinence in men.
There are different types of urinary incontinence in men, including stress incontinence, urge incontinence, and overflow incontinence.
Diagnosis of urinary incontinence in men may involve a physical exam, an ultrasound, urodynamic testing, and tests including an electroencephalogram (EEG) and an electromyogram (EMG). The doctor will also take a medical history and may recommend keeping a bladder diary.
Treatment of urinary incontinence in men may include behavioral treatments, like bladder training and Kegel exercises, medication, surgery, or...

Read the Urinary Incontinence article »

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Detrol

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Detrol®
(tolterodine tartrate) Tablets

DRUG DESCRIPTION

DETROL Tablets contain tolterodine tartrate. The active moiety, tolterodine, is a muscarinic receptor antagonist. The chemical name of tolterodine tartrate is (R)-2-[3[bis(1-methylethyl)-amino]1-phenylpropyl]-4-methylphenol [R-(R*,R*)]2,3dihydroxybutanedioate (1:1) (salt). The empirical formula of tolterodine tartrate is C₂₆H₃₇NO₇, and its molecular weight is 475.6. The structural formula of tolterodine tartrate is represented below:

Detrol® (tolterodine tartrate) Structural Formula Illustration

Tolterodine tartrate is a white, crystalline powder. The pKa value is 9.87 and the solubility in water is 12 mg/mL. It is soluble in methanol, slightly soluble in ethanol, and practically insoluble in toluene. The partition coefficient (Log D) between n-octanol and water is 1.83 at pH 7.3.

DETROL Tablets for oral administration contain 1 or 2 mg of tolterodine tartrate. The inactive ingredients are colloidal anhydrous silica, calcium hydrogen phosphate dihydrate, cellulose microcrystalline, hypromellose, magnesium stearate, sodium starch glycolate (pH 3.0 to 5.0), stearic acid, and titanium dioxide.

What are the possible side effects of tolterodine (Detrol, Detrol LA)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using tolterodine and call your doctor at once if you have any of these serious side effects:

chest pain, fast or uneven heart rate;
feeling short of breath, even with mild exertion;
swelling, rapid weight gain;
confusion, hallucinations;
urinating less than usual or not at all; or
painful or...

Read All Potential Side Effects and See Pictures of Detrol »

What are the precautions when taking tolterodine tartrate (Detrol)?

Before taking tolterodine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: problems emptying your bladder (urinary retention), severe blockage of stomach/intestines (gastric retention), a certain eye condition (uncontrolled narrow-angle glaucoma).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other bladder problems (e.g., bladder outflow obstruction), stomach/intestinal disease (e.g.,...

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Last reviewed on RxList: 9/28/2011
This monograph has been modified to include the generic and brand name in many instances.