Detrol (Tolterodine Tartrate) Drug Information: Overdosage and Contraindications

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May 27, 2012

Detrol

Urinary Incontinence in Children »

Urinary incontinence in children facts

Urinary incontinence in children is very common.
Nighttime wetting (nocturnal enuresis) is more common than daytime wetting (diurnal enuresis).
Most urinary incontinence is nonorganic and resolves without intervention.
Persistent primary enuresis and secondary enuresis may require further medical evaluation.
Treatment for most cases of enuresis involves behavioral modification.
Bedwetting alarms are very effective.
Medications should be reserved for select children.
Less than 1% of all affected children have persistent incontinence into adulthood.

What is urinary incontinence?

Very simply stated, urinary incontinence is defined as the loss of complete control of the act of urination or the involuntary emptying of the bladder. It is also referred to as enuresis. It can be caused by any number of factors,...

Read the Urinary Incontinence in Children article »

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OVERDOSE

A 27-month-old child who ingested 5 to 7 DETROL Tablets 2 mg was treated with a suspension of activated charcoal and was hospitalized overnight with symptoms of dry mouth. The child fully recovered.

Management of Overdosage

Overdosage with DETROL can potentially result in severe central anticholinergic effects and should be treated accordingly.

ECG monitoring is recommended in the event of overdosage. In dogs, changes in the QT interval (slight prolongation of 10% to 20%) were observed at a suprapharmacologic dose of 4.5 mg/kg, which is about 68 times higher than the recommended human dose. In clinical trials of normal volunteers and patients, QT interval prolongation was observed with tolterodine immediate release at doses up to 8 mg (4 mg bid) and higher doses were not evaluated (see PRECAUTIONS, Patients with Congenital or Acquired QT Prolongation).

CONTRAINDICATIONS

DETROL Tablets are contraindicated in patients with urinary retention, gastric retention, or uncontrolled narrow-angle glaucoma. DETROL is also contraindicated in patients who have demonstrated hypersensitivity to the drug or its ingredients, or to fesoterodine fumarate extended-release tablets which, like DETROL, are metabolized to 5hydroxymethyl tolterodine.

Last reviewed on RxList: 9/28/2011
This monograph has been modified to include the generic and brand name in many instances.