Detrol LA (Tolterodine Tartrate) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Detrol LA

Overactive Bladder »

What is an overactive bladder?

An overactive bladder is a condition that results from sudden, involuntary contraction of the muscle in the wall of the urinary bladder. Overactive bladder causes a sudden and unstoppable need to urinate (urinary urgency), even though the bladder may only contain a small amount of urine.

Overactive bladder is also referred to as urge incontinence and is a form of urinary incontinence (unintentional loss of urine). Another common type of urinary incontinence is called stress incontinence, which is caused by anatomic weakness in the structures that prevent the bladder from leaking. In general, urinary incontinence is more common in women compared to men.

Although it can happen at any age, overactive bladder is especially common in older adults. Overactive bladder affects an estimated one in 11 adults in the United States. Overactive bladder, however, should not be considered a normal part of aging.

...

Read the Overactive Bladder article »

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Detrol LA

Urinary Incontinence in Women Slideshow Pictures

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Detrol® LA
(tolterodine tartrate) Extended Release Capsules
For oral administration

DRUG DESCRIPTION

DETROL LA Capsules contain tolterodine tartrate. The active moiety, tolterodine, is a muscarinic receptor antagonist. The chemical name of tolterodine tartrate is (R)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate. The empirical formula of tolterodine tartrate is C₂₆H₃₇NO₇,. Its structure is:

Detrol® LA
(tolterodine tartrate) Structural Formula Illustration

Tolterodine tartrate is a white, crystalline powder with a molecular weight of 475.6. The pK_a value is 9.87 and the solubility in water is 12 mg/mL. It is soluble in methanol, slightly soluble in ethanol, and practically insoluble in toluene. The partition coefficient (Log D) between n-octanol and water is 1.83 at pH 7.3.

DETROL LA 4 mg capsule for oral administration contains 4 mg of tolterodine tartrate. Inactive ingredients are sucrose, starch, hypromellose, ethylcellulose, medium chain triglycerides, oleic acid, gelatin, and FD&C Blue #2.

DETROL LA 2 mg capsule for oral administration contains 2 mg of tolterodine tartrate, and the following inactive ingredients: sucrose, starch, hypromellose, ethylcellulose, medium chain triglycerides, oleic acid, gelatin, yellow iron oxide, and FD&C Blue #2.

Both the 2 mg and 4 mg capsule strengths are imprinted with a pharmaceutical grade printing ink that contains shellac glaze, titanium dioxide, propylene glycol, and simethicone.

What are the possible side effects of tolterodine (Detrol, Detrol LA)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using tolterodine and call your doctor at once if you have any of these serious side effects:

chest pain, fast or uneven heart rate;
feeling short of breath, even with mild exertion;
swelling, rapid weight gain;
confusion, hallucinations;
urinating less than usual or not at all; or
painful or...

Read All Potential Side Effects and See Pictures of Detrol LA »

What are the precautions when taking tolterodine tartrate (Detrol LA)?

Before taking tolterodine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: problems emptying your bladder (urinary retention), severe blockage of stomach/intestines (gastric retention), a certain eye condition (uncontrolled narrow-angle glaucoma).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other bladder problems (e.g., bladder outflow obstruction), stomach/intestinal disease (e.g.,...

Read All Potential Precautions of Detrol LA »

Last reviewed on RxList: 10/3/2011
This monograph has been modified to include the generic and brand name in many instances.