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Dexedrine Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Dexedrine (dextroamphetamine sulfate) is used to treat narcolepsy and attention deficit hyperactivity disorder (ADHD). It is a central nervous system stimulant. This medication is available in generic form. Common side effects include nausea, stomach upset, cramps, loss of appetite, diarrhea, dry mouth, headache, nervousness, dizziness, trouble sleeping, sweating, weight loss, irritability or restlessness.
The usual dose of Dexedrine to treat narcolepsy is 5 to 60 mg per day in divided doses, depending on the patient response. For treatment of ADHD in pediatric patients 6 years of age and older, start with 5 mg once or twice daily; daily dosage may be raised by a physician. Dexedrine may interact with blood pressure medications, diuretics (water pills), antihistamines, acetazolamide, chlorpromazine, ethosuximide, guanethidine, haloperidol, lithium, methenamine, phenytoin, phenobarbital, sodium bicarbonate (Alka-Seltzer), or antidepressants. Tell your doctor all medications you are taking. Dexedrine should be used only if prescribed during pregnancy. Infants born to mothers who are dependent on this medication may be born too soon (premature) and have low birth weight. They may also have withdrawal symptoms. Tell your doctor if you notice mood changes, agitation, or unusual tiredness in your newborn. This medication passes into breast milk and may have undesirable effects on a nursing infant. Breast-feeding is not recommended. Dexedrine may be habit-forming. Withdrawal symptoms may occur after stopping this drug.
Our Dexedrine (dextroamphetamine sulfate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Dexedrine in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have a serious side effect such as:
- fast or pounding heartbeats;
- feeling light-headed, fainting;
- dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure); or
- tremor, restlessness, hallucinations, unusual behavior, or motor tics (muscle twitches).
Less serious side effects may include:
- headache or dizziness;
- sleep problems (insomnia);
- dry mouth or an unpleasant taste in your mouth;
- diarrhea, constipation;
- loss of appetite, weight loss; or
- loss of interest in sex, impotence, or difficulty having an orgasm.
Read the entire detailed patient monograph for Dexedrine (Dextroamphetamine) »
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Dexedrine Overview - Patient Information: Side Effects
Remember that your doctor has prescribed this medicine because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: mental/mood/behavior changes (e.g., agitation, aggression, mood swings, depression, hallucinations, abnormal thoughts/behavior), uncontrolled movements, muscle twitching/shaking, outbursts of words/sounds, change in sexual ability/interest, swelling of the ankles/feet, extreme tiredness, significant unexplained weight loss.
Seek immediate medical attention if any of these rare but very serious side effects occur: shortness of breath, chest pain, severe headache, fast/pounding/irregular heartbeat, jaw/left arm pain, seizures, weakness on one side of the body, slurred speech, confusion, fainting, blurred vision.
A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Dexedrine (Dextroamphetamine)»
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Dexedrine FDA Prescribing Information: Side Effects
Central Nervous System: Psychotic episodes at recommended doses (rare), overstimulation, restlessness, dizziness, insomnia, euphoria, dyskinesia, dysphoria, tremor, headache, exacerbation of motor and phonic tics, and Tourette's syndrome.
Drug Abuse And Dependence
Dextroamphetamine sulfate is a Schedule II controlled substance.
Amphetamines have been extensively abused. Tolerance, extreme psychological dependence and severe social disability have occurred. There are reports of patients who have increased the dosage to many times that recommended. Abrupt cessation following prolonged high dosage administration results in extreme fatigue and mental depression; changes are also noted on the sleep EEG.
Manifestations of chronic intoxication with amphetamines include severe dermatoses, marked insomnia, irritability, hyperactivity, and personality changes. The most severe manifestation of chronic intoxication is psychosis, often clinically indistinguishable from schizophrenia. This is rare with oral amphetamines.
Read the entire FDA prescribing information for Dexedrine (Dextroamphetamine) »
Additional Dexedrine Information
Dexedrine - User Reviews
Dexedrine User Reviews
Now you can gain knowledge and insight about a drug treatment with Patient Discussions.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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