February 13, 2016
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Dexilant

"The U.S. Food and Drug Administration today approved the first generic versions of Aciphex (rabeprazole sodium) delayed-release tablets, used to treat gastroesophageal reflux disease (GERD) in adults and adolescents (ages 12 and up).

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Dexilant




Overdosage
Contraindications

OVERDOSE

There have been no reports of significant overdose of DEXILANT. Multiple doses of DEXILANT 120 mg and a single dose of DEXILANT 300 mg did not result in death or other severe adverse events. However, serious adverse events of hypertension have been reported in association with twice daily doses of DEXILANT 60 mg. Non-serious adverse reactions observed with twice daily doses of DEXILANT 60 mg include hot flashes, contusion, oropharyngeal pain, and weight loss. Dexlansoprazole is not expected to be removed from the circulation by hemodialysis.

In the event of over-exposure, treatment should be symptomatic and supportive.

If over-exposure occurs, call your poison control center at 1-800-222-1222 for current information on the management of poisoning or over-exposure.

CONTRAINDICATIONS

  • DEXILANT is contraindicated in patients with known hypersensitivity to any component of the formulation [see DESCRIPTION]. Hypersensitivity reactions, including anaphylaxis have been reported [see ADVERSE REACTIONS]. Acute interstitial nephritis (AIN) has been reported with other proton pump inhibitors (PPIs), including lansoprazole of which dexlansoprazole is the R-enantiomer.
  • PPIs, including DEXILANT, are contraindicated with rilpivirine-containing products [see DRUG INTERACTIONS].
This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 2/12/2016

Overdosage
Contraindications

Dexilant - User Reviews

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