Dextrose 5% in 0.9% Sodium Chloride (Dextrose and Sodium Chloride Inj) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 10, 2012

Dextrose 5% in 0.9% Sodium Chloride

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Dextrose and Sodium Chloride Injection, USP (dextrose and sodium chloride inj)
in VIAFLEX Plastic Container

DRUG DESCRIPTION

Dextrose and Sodium Chloride Injection, USP (dextrose and sodium chloride inj) is a sterile, nonpyrogenic solution for fluid and electrolyte replenishment and caloric supply in single dose containers for intravenous administration. It contains no antimicrobial agents. Composition, osmolarity, pH, ionic concentration and caloric content are shown in Table 1.

Table 1

	Size (mL)	Composition (g/L)		(calc.) *Osmolarity (mOsmol/L) (calc.)	pH	Ionic Concentration (mEq/L)		Caloric Content (kcal/L)
		** Dextrose Hydrous, USP	Sodium Chloride, USP (NaCl)			Ionic Concentration (mEq/L)
		** Dextrose Hydrous, USP	Sodium Chloride, USP (NaCl)			Sodium	Chloride
2.5% Dextrose and 0.45% Sodium Chloride Injection, USP	500 1000	25	4.5	280	4.5 (3.2 to 6.5)	77	77	85
5% Dextrose and 0.2% Sodium Chloride Injection, USP	250 500 1000	50	2	321	4.0 (3.2 to 6.5)	34	34	170
5% Dextrose and 0.33% Sodium Chloride Injection, USP	250 500 1000	50	3.3	365	4.0 (3.2 to 6.5)	56	56	170
5% Dextrose and 0.45% Sodium Chloride Injection, USP	250 500 1000	50	4.5	406	4.0 (3.2 to 6.5)	77	77	170
5% Dextrose and 0.9% Sodium Chloride Injection, USP	250 500 1000	50	9	560	4.0 (3.2 to 6.5)	154	154	170
10% Dextrose and 0.9% Sodium Chloride Injection, USP	500 1000	100	9	813	4.0 (3.2 to 6.5)	154	154	340
*Normal physiologic osmolarity range is approximately 280 to 310 mOsmol/L. Administration of substantially hypertonic solutions ( ≥ 600 mOsmol/L) may cause vein damage.

Dextrose and Sodium Chloride Structural Formula Illustration

The VIAFLEX plastic container is fabricated from a specially formulated polyvinyl chloride (PL 146 Plastic). The amount of water that can permeate from inside the container into the overwrap is insufficient to affect the solution significantly. Solutions in contact with the plastic container can leach out certain of its chemical components in very small amounts within the expiration period, e.g., di-2-ethylhexyl phthalate (DEHP), up to 5 parts per million. However, the safety of the plastic has been confirmed in tests in animals according to USP biological tests for plastic containers as well as by tissue culture toxicity studies.

Last reviewed on RxList: 10/3/2008
This monograph has been modified to include the generic and brand name in many instances.