DiaBeta (Glyburide Tablets) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

Diabeta

Oral Diabetes Prescription Medications »

What are oral diabetes medications and how do they work?

Insulin is a hormone produced by cells in the pancreas called beta cells. Insulin helps the body use blood glucose (a type of sugar) for energy. People with type 2 diabetes do not make enough insulin and/or their bodies do not respond well to it, leading to elevated blood sugar levels. Oral diabetes medications bring blood sugar levels into the normal range through a variety of ways.

For what conditions are diabetes pills used?

Oral diabetes medications are only used to treat type 2 or non-insulin-dependent diabetes. Patients with type 1 diabetes are dependent on insulin for their treatment.

Are there differences among types of oral diabetes medications?

Medications that increase insulin production

The earliest oral diabetes drugs were the sulfonylureas. These work by stimulating the pancreas to produce more insu...

Read the Oral Diabetes Prescription Medications article »

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DiaBeta

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Diaβeta®
(glyburide) Tablets USP 1.25, 2.5 and 5 mg

DRUG DESCRIPTION

Diaβeta® (glyburide) is an oral blood-glucose-lowering drug of the sulfonylurea class. It is a white, crystalline compound, formulated as tablets of 1.25 mg, 2.5 mg, and 5 mg strengths for oral administration. Diaβeta tablets USP contain the active ingredient glyburide and the following inactive ingredients: dibasic calcium phosphate USP, magnesium stearate NF, microcrystalline cellulose NF, sodium alginate NF, talc USP. Diaβeta (glyburide tablets) 1.25 mg tablets USP also contain D&C Yellow #10 Aluminum Lake and FD&C Red #40 Aluminum Lake. Diaβeta (glyburide tablets) 2.5 mg tablets USP also contain FD&C Red #40 Aluminum Lake. Diaβeta (glyburide tablets) 5 mg tablets USP also contain D&C Yellow #10 Aluminum Lake, and FD&C Blue #1. Chemically, Diaβeta (glyburide tablets) is identified as 1-[[p-[2-(5-Chloro-o-anisamido)ethyl]phenyl]sulfonyl]-3-cyclohexylurea.

The CAS Registry Number is 10238-21-8.

The structural formula is:

Diaβeta (glyburide) Structural Formula Illustration

The molecular weight is 493.99. The aqueous solubility of Diaβeta (glyburide tablets) increases with pH as a result of salt formation.

What are the possible side effects of glyburide (DiaBeta, Glynase PresTab, Micronase)?

Stop using glyburide and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
pale skin, confusion or weakness;
easy bruising or bleeding, purple or red pinpoint spots under...

Read All Potential Side Effects and See Pictures of DiaBeta »

Last reviewed on RxList: 8/3/2009
This monograph has been modified to include the generic and brand name in many instances.