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DiaBeta

Last reviewed on RxList: 1/30/2017
Diabeta Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 01/25/2017

DiaBeta (glyburide) Tablets is a diabetes medicine used to help control blood sugar levels and treat type 2 diabetes. DiaBeta is available in generic form. Common side effects of DiaBeta include:

DiaBeta can also cause low blood sugar (hypoglycemia). Symptoms of low blood sugar include sweating, shaking, fast heartbeat, hunger, dizziness, or tingling hands/feet. Tell your doctor if you have serious side effects of DiaBeta including:

Talk to your doctor about your individual dosage recommendation. Warfarin, Neoral, Norpace, Nizoral, Prozac, Proventil, Toprol, diuretics, steroids, Synthroid, birth control pills, heart or blood pressure medications, niacin, seizure medicines, and medicines to treat asthma, colds or allergies may interact with DiaBeta. Tell your doctor all medications you take. Before taking DiaBeta tell your doctor if you have hemolytic anemia, an enzyme deficiency, a nerve disorder, liver disease, or kidney disease. If you are pregnant only use DiaBeta if the potential benefits outweigh the potential risks to the fetus. Do not take DiaBeta if you are breastfeeding.

Our DiaBeta (glyburide) Tablets Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Diabeta Consumer Information

Stop using glyburide and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking this medication and call your doctor at once if you have any of these serious side effects:

  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • pale skin, confusion or weakness;
  • easy bruising or bleeding, purple or red pinpoint spots under your skin; or
  • headache, trouble concentrating, memory problems, feeling unsteady, hallucinations, fainting, seizure, shallow breathing or breathing that stops.

Less serious side effects may include:

  • mild nausea, heartburn, feeling full;
  • joint or muscle pain;
  • blurred vision; or
  • mild itching or skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Diabeta (Glyburide Tablets)

Diabeta Professional Information

SIDE EFFECTS

Hypoglycemia

See PRECAUTIONS and OVERDOSE Sections.

Gastrointestinal Reactions

Cholestatic jaundice and hepatitis may occur rarely which may progress to liver failure; Diaβeta should be discontinued if this occurs. Liver function abnormalities, including isolated transaminase elevations, have been reported. Gastrointestinal disturbances, e.g., nausea, epigastric fullness, and heartburn, are the most common reactions and occur in 1.8% of treated patients. They tend to be dose-related and may disappear when dosage is reduced.

Dermatologic Reactions

Allergic skin reactions, e.g., pruritus, erythema, urticaria, and morbilliform or maculopapular eruptions, occur in 1.5% of treated patients. These may be transient and may disappear despite continued use of Diaβeta. Bullous reactions, erythema multiforme, and exfoliative dermatitis, have been reported. If skin reactions persist, the drug should be discontinued.

Porphyria cutanea tarda and photosensitivity reactions have been reported with sulfonylureas.

Hematologic Reactions

Leukopenia, agranulocytosis, thrombocytopenia, which occasionally may present as purpura, hemolytic anemia, aplastic anemia, and pancytopenia have been reported with sulfonylureas.

Metabolic Reactions

Hepatic porphyria reactions have been reported with sulfonylureas; however, these have not been reported with Diaβeta. Disulfiram-like reactions have been reported very rarely with Diaβeta. Cases of hyponatremia have been reported with glyburide and all other sulfonylureas, most often in patients who are on other medications or have medical conditions known to cause hyponatremia or increase release of antidiuretic hormone. The syndrome of inappropriate antidiuretic hormone (SIADH) secretion has been reported with certain other sulfonylureas, and it has been suggested that these sulfonylureas may augment the peripheral (antidiuretic) action of ADH and/or increase release of ADH. Diaβeta can cause weight gain.

Other Reactions

Changes in accommodation and/or blurred vision have been reported with glyburide and other sulfonylureas. These are thought to be related to fluctuation in glucose levels.

In addition to dermatologic reactions, allergic reactions such as angioedema, arthralgia, myalgia and vasculitis have been reported.

Read the entire FDA prescribing information for Diabeta (Glyburide Tablets)

Related Resources for Diabeta

© Diabeta Patient Information is supplied by Cerner Multum, Inc. and Diabeta Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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