Diabinese (Chlorpropamide) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 8, 2012

Diabinese

Oral Diabetes Prescription Medications »

What are oral diabetes medications and how do they work?

Insulin is a hormone produced by cells in the pancreas called beta cells. Insulin helps the body use blood glucose (a type of sugar) for energy. People with type 2 diabetes do not make enough insulin and/or their bodies do not respond well to it, leading to elevated blood sugar levels. Oral diabetes medications bring blood sugar levels into the normal range through a variety of ways.

For what conditions are diabetes pills used?

Oral diabetes medications are only used to treat type 2 or non-insulin-dependent diabetes. Patients with type 1 diabetes are dependent on insulin for their treatment.

Are there differences among types of oral diabetes medications?

Medications that increase insulin production

The earliest oral diabetes drugs were the sulfonylureas. These work by stimulating the pancreas to produce more insu...

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DIABINESE®
(chlorpropamide) Tablets, USP
For Oral Use

DRUG DESCRIPTION

DIABINESE® (chlorpropamide), is an oral blood-glucose-lowering drug of the sulfonylurea class. Chlorpropamide is l-[(p-Chlorophenyl)sulfonyl]-3-propylurea, C₁₀H₁₃ClN₂O₃S, and has the structural formula:

DIABINESE®
(chlorpropamide) Structural Formula Illustration

Chlorpropamide is a white crystalline powder, that has a slight odor. It is practically insoluble in water at pH 7.3 (solubility at pH 6 is 2.2 mg/mL). It is soluble in alcohol and moderately soluble in chloroform. The molecular weight of chlorpropamide is 276.74. DIABINESE (chlorpropamide) is available as 100 mg and 250 mg tablets.

Inert ingredients are: alginic acid; Blue 1 Lake; hydroxypropyl cellulose; magnesium stearate; precipitated calcium carbonate; sodiukm lauryl sulfate; starch.

What are the possible side effects of chlorpropamide (Diabinese)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Hypoglycemia, or low blood sugar, is the most common side effect of chlorpropamide. Symptoms of low blood sugar may include headache, nausea, hunger, confusion, drowsiness, weakness, dizziness, blurred vision, fast heartbeat, sweating, tremor, trouble concentrating, confusion, or seizure (convulsions). Watch for signs of low blood sugar. Carry a piece of non-dietetic...

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What are the precautions when taking chlorpropamide (Diabinese)?

Before taking chlorpropamide, tell your doctor or pharmacist if you are allergic to it; or to other sulfonylurea drugs (e.g., tolbutamide); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: a certain metabolic condition (diabetic ketoacidosis).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, thyroid problems, poor diet, irregular eating patterns, certain hormonal conditions (adrenal/pituitary insufficiency,...

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Last reviewed on RxList: 3/25/2011
This monograph has been modified to include the generic and brand name in many instances.