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Diabinese

Last reviewed on RxList: 4/25/2017
Diabinese Side Effects Center

Last reviewed on RxList 02/21/2017

Diabinese (chlorpropamide) is an oral diabetes medicine used together with diet and exercise to treat type 2 (non-insulin dependent) diabetes. Other diabetes medicines are sometimes used with Diabinese if needed. Diabinese is available in generic form. Common side effects of Diabinese include:

The most common side effect of Diabinese is low blood sugar (hypoglycemia). Tell your doctor if you experience symptoms of low blood sugar including headache, hunger, weakness, sweating, tremors, irritability, trouble concentrating, rapid breathing, fast heartbeat, fainting, or seizure (severe hypoglycemia can be fatal). Tell your doctor if you have serious side effects of Diabinese including:

  • skin changes (such as darkening, thickening),
  • unusual fatigue,
  • fast or pounding heartbeat,
  • easy bruising or bleeding,
  • mental/mood changes,
  • sudden weight gain,
  • swelling of the hands or feet,
  • muscle weakness or spasm,
  • painful bowel movements,
  • bloody or black stools,
  • yellowing eyes or skin,
  • persistent nausea or vomiting,
  • severe stomach or abdominal pain,
  • dark urine,
  • signs of infection (such as fever, persistent sore throat), or
  • seizures.

The initial dosage range for Diabinese for mild to moderately severe, middle-aged, stable type 2 diabetes patients is 250 mg daily. High blood sugar (hyperglycemia) may result if you take Diabinese with drugs that raise blood sugar, such as: isoniazid, diuretics (water pills), steroids, phenothiazines, thyroid medicine, birth control pills and other hormones, seizure medicines, diet pills, medicines to treat asthma, colds or allergies. Low blood sugar (hypoglycemia) may result if you take Diabinese with drugs that lower blood sugar, such as: nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), beta-blockers, probenecid, or blood thinners. Tell your doctor all medications you use. Diabinese should be used only when prescribed during pregnancy. It is not recommended for use for at least 1 month before delivery because it may cause low blood sugar in newborns. Your doctor may substitute insulin during your pregnancy. This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.

Our Diabinese (chlorpropamide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Diabinese Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Hypoglycemia, or low blood sugar, is the most common side effect of chlorpropamide. Symptoms include headache, hunger, weakness, sweating, tremors, irritability, trouble concentrating, rapid breathing, fast heartbeat, fainting, or seizure (severe hypoglycemia can be fatal). Carry hard candy or glucose tablets with you in case you have low blood sugar.

Stop taking chlorpropamide and call your doctor at once if you have a serious side effect such as:

  • easy bruising or bleeding, unusual weakness;
  • pale skin, fever, confusion;
  • trouble concentrating, memory problems, feeling unsteady, hallucinations;
  • feeling light-headed, fainting;
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • throbbing headache, sweating, severe nausea, trouble breathing, fast or pounding heartbeats, blurred vision, spinning sensation; or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • mild nausea, vomiting, diarrhea;
  • mild hunger; or
  • mild skin rash, redness, or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Diabinese (Chlorpropamide)

Diabinese Professional Information

SIDE EFFECTS

Body as a Whole: Disulfiram-like reactions have rarely been reported with DIABINESE (chlorpropamide) (see DRUG INTERACTIONS).

Central and Peripheral Nervous System: Dizziness and headache.

Hypoglycemia: See PRECAUTIONS and OVERDOSAGE sections.

Gastrointestinal: Gastrointestinal disturbances are the most common reactions; nausea has been reported in less than 5% of patients, and diarrhea, vomiting, anorexia, and hunger in less than 2%. Other gastrointestinal disturbances have occurred in less than 1% of patients including proctocolitis. They tend to be dose-related and may disappear when dosage is reduced.

Liver/Biliary: Cholestatic jaundice and hepatitis may occur rarely, which may progress to liver failure; DIABINESE (chlorpropamide) should be discontinued if this occurs. Hepatic porphyria and disulfiram-like reactions have been reported with DIABINESE (chlorpropamide) .

Skin/Appendages: Pruritus has been reported in less than 3% of patients. Other allergic skin reactions, e.g., urticaria and maculopapular eruptions have been reported in approximately 1% or less of patients. These may be transient and may disappear despite continued use of DIABINESE (chlorpropamide) ; if skin reactions persist the drug should be discontinued.

As with other sulfonylureas, porphyria cutanea tarda and photosensitivity reactions have been reported.

Skin eruptions rarely progressing to erythema multiforme and exfoliative dermatitis have also been reported.

Hematologic Reactions: Leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia (see PRECAUTIONS), aplastic anemia, pancytopenia, and eosinophilia have been reported with sulfonylureas.

Metabolic/Nutritional Reactions: Hypoglycemia (see PRECAUTIONS and OVERDOSAGE sections). Hepatic porphyria and disulfiram-like reactions have been reported with DIABINESE (chlorpropamide) . See DRUG INTERACTIONS section.

Endocrine Reactions: On rare occasions, chlorpropamide has caused a reaction identical to the syndrome of inappropriate antidiuretic hormone (ADH) secretion. The features of this syndrome result from excessive water retention and include hyponatremia, low serum osmolality, and high urine osmolality. This reaction has also been reported for other sulfonylureas.

Read the entire FDA prescribing information for Diabinese (Chlorpropamide)

Related Resources for Diabinese

Read the Diabinese User Reviews »

© Diabinese Patient Information is supplied by Cerner Multum, Inc. and Diabinese Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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