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Diazepam Injection Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Diazepam Injection (brand name: Valium) is a benzodiazepine used to treat anxiety and muscle spasms. The injection form of diazepam is used when the medication cannot be taken by mouth. Diazepam injection is also used in patients with alcohol withdrawal to prevent seizures and treat other symptoms (e.g., agitation, anxiety, hallucinations), for short-term treatment of serious seizures that do not stop (status epilepticus), or before surgeries or procedures to cause drowsiness, decrease anxiety, and cause forgetfulness about the procedure or surgery. Diazepam injection is available in generic form. Common side effects of diazepam injection include drowsiness, dizziness, nausea, poor coordination, unsteadiness, headache, sleep disturbances, low blood pressure, skin rash, or pain/burning/redness/blood clot at the injection site.
Dosage of Diazepam Injection depends on the condition being treated and its severity. The usual recommended dose in older children and adults ranges from 2 mg to 20 mg I.M. or I.V. Diazepam Injection may interact with fluvoxamine, kava, phenytoin, cimetidine, ketoconazole, omeprazole, antihistamines, anti-seizure drugs, medicine for sleep or anxiety, muscle relaxants, narcotics, or psychiatric medicines. This medication contains a small amount of alcohol. Tell your doctor if you are taking drugs such as disulfiram or metronidazole that can adversely interact with alcohol. Diazepam Injection is not recommended for use during pregnancy. It may harm a fetus. This drug may pass into breast milk and have undesirable effects on a nursing infant. Breast-feeding while using this medication is not recommended. Diazepam Injection may cause withdrawal symptoms (shakiness, trouble sleeping, muscle cramps, vomiting, sweating, seizures, mental/mood changes such as anxiety/agitation) if you suddenly stop using this medication.
Our Diazepam Injection (brand name: Valium) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Diazepam Injection Overview - Patient Information: Side Effects
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: fainting, fast/irregular heartbeat, mental/mood changes (e.g., confusion, depression, strange thoughts), muscle weakness, pain/swelling/signs of infection at the injection site, vision changes (e.g., blurred/double vision), slow/shallow breathing, easy bleeding/bruising, chest pain, loss of consciousness, signs of infection (e.g., fever, persistent sore throat), slurred speech, severe stomach/abdominal pain, unusual tiredness, dark urine, difficulty walking, yellowing eyes/skin.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Diazepam Injection (Diazepam Injection)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Diazepam Injection FDA Prescribing Information: Side Effects
CNS: confusion, depression, dysarthria, headache, hypoactivity, slurred speech, syncope, tremor, vertigo. G.I.: constipation, nausea. G.U.: incontinence, changes in libido, urinary retention. Cardiovascular : bradycardia, cardiovascular collapse, hypotension. EENT: blurred vision, diplopia, nystagmus. Skin: urticaria, skin rash. Other: hiccups, changes in salivation, neutropenia, jaundice. Paradoxical reactions such as acute hyperexcited states, anxiety, hallucinations, increased muscle spasticity, insomnia, rage, sleep disturbances and stimulation have been reported; should these occur, use of the drug should be discontinued. Minor changes in EEG patterns, usually low-voltage fast activity, have been observed in patients during and after diazepam therapy and are of no known significance.
Because of isolated reports of neutropenia and jaundice, periodic blood counts and liver function tests are advisable during long-term therapy.
Drug Abuse And Dependence
Withdrawal symptoms, similar in character to those noted with barbiturates and alcohol (convulsions, tremor, abdominal and muscle cramps, vomiting and sweating), have occurred following abrupt discontinuance of diazepam. The more severe withdrawal symptoms have usually been limited to those patients who had received excessive doses over an extended period of time. Generally milder withdrawal symptoms (e.g., dysphoria and insomnia) have been reported following abrupt discontinuance of benzodiazepines taken continuously at therapeutic levels for several months. Consequently, after extended therapy, abrupt discontinuation should generally be avoided and a gradual dosage tapering schedule followed. Addiction-prone individuals (such as drug addicts or alcoholics) should be under careful surveillance when receiving diazepam or other psychotropic agents because of the predisposition of such patients to habituation and dependence.
Read the entire FDA prescribing information for Diazepam Injection (Diazepam Injection)
Additional Diazepam Injection Information
Diazepam Injection - User Reviews
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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