Diazepam Injection

Diazepam Injection

Diazepam Injection Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Diazepam Injection (brand name: Valium) is used to treat anxiety and muscle spasms. The injection form is used when the medication cannot be taken by mouth. It is also used in patients with alcohol withdrawal to prevent seizures and treat other symptoms (e.g., agitation, anxiety, hallucinations), for short-term treatment of serious seizures that do not stop (status epilepticus), or before surgeries or procedures to cause drowsiness, decrease anxiety, and cause forgetfulness about the procedure or surgery. This medication belongs to a class of drugs called benzodiazepines. It is available in generic form. Common side effects include drowsiness, dizziness, nausea, unsteadiness, or pain/burning/redness at the injection site.

Dosage of Diazepam Injection depends on the condition being treated and its severity. The usual recommended dose in older children and adults ranges from 2 mg to 20 mg I.M. or I.V. Diazepam Injection may interact with fluvoxamine, kava, phenytoin, cimetidine, ketoconazole, omeprazole, antihistamines, anti-seizure drugs, medicine for sleep or anxiety, muscle relaxants, narcotics, or psychiatric medicines. This medication contains a small amount of alcohol. Tell your doctor if you are taking drugs such as disulfiram or metronidazole that can adversely interact with alcohol. Diazepam Injection is not recommended for use during pregnancy. It may harm a fetus. This drug may pass into breast milk and have undesirable effects on a nursing infant. Breast-feeding while using this medication is not recommended. Diazepam Injection may cause withdrawal symptoms (shakiness, trouble sleeping, muscle cramps, vomiting, sweating, seizures, mental/mood changes such as anxiety/agitation) if you suddenly stop using this medication.

Our Diazepam Injection (brand name: Valium) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Diazepam Injection FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

Side effects most commonly reported were drowsiness, fatigue and ataxia; venous thrombosis and phlebitis at the site of injection. Other adverse reactions less frequently reported include:

CNS: confusion, depression, dysarthria, headache, hypoactivity, slurred speech, syncope, tremor, vertigo. G.I.: constipation, nausea. G.U.: incontinence, changes in libido, urinary retention. Cardiovascular : bradycardia, cardiovascular collapse, hypotension. EENT: blurred vision, diplopia, nystagmus. Skin: urticaria, skin rash. Other: hiccups, changes in salivation, neutropenia, jaundice. Paradoxical reactions such as acute hyperexcited states, anxiety, hallucinations, increased muscle spasticity, insomnia, rage, sleep disturbances and stimulation have been reported; should these occur, use of the drug should be discontinued. Minor changes in EEG patterns, usually low-voltage fast activity, have been observed in patients during and after diazepam therapy and are of no known significance.

In peroral endoscopic procedures, coughing, depressed respiration, dyspnea, hyperventilation, laryngospasm and pain in throat or chest have been reported.

Because of isolated reports of neutropenia and jaundice, periodic blood counts and liver function tests are advisable during long-term therapy.

Drug Abuse And Dependence

Diazepam Injection is classified by the Drug Enforcement Administration as a schedule IV controlled substance.

Withdrawal symptoms, similar in character to those noted with barbiturates and alcohol (convulsions, tremor, abdominal and muscle cramps, vomiting and sweating), have occurred following abrupt discontinuance of diazepam. The more severe withdrawal symptoms have usually been limited to those patients who had received excessive doses over an extended period of time. Generally milder withdrawal symptoms (e.g., dysphoria and insomnia) have been reported following abrupt discontinuance of benzodiazepines taken continuously at therapeutic levels for several months. Consequently, after extended therapy, abrupt discontinuation should generally be avoided and a gradual dosage tapering schedule followed. Addiction-prone individuals (such as drug addicts or alcoholics) should be under careful surveillance when receiving diazepam or other psychotropic agents because of the predisposition of such patients to habituation and dependence.

Read the entire FDA prescribing information for Diazepam Injection (Diazepam Injection) »

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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