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Dibenzyline

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Dibenzyline

Dibenzyline

INDICATIONS

Dibenzyline (phenoxybenzamine) is indicated in the treatment of pheochromocytoma, to control episodes of hypertension and sweating. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly.

DOSAGE AND ADMINISTRATION

The dosage should be adjusted to fit the needs of each patient. Small initial doses should be slowly increased until the desired effect is obtained or the side effects from blockade become troublesome. After each increase, the patient should be observed on that level before instituting another increase. The dosage should be carried to a point where symptomatic relief and/or objective improvement are obtained, but not so high that the side effects from blockade become troublesome.

Initially, 10 mg of Dibenzyline (phenoxybenzamine hydrochloride) twice a day. Dosage should be increased every other day, usually to 20 to 40 mg 2 or 3 times a day, until an optimal dosage is obtained, as judged by blood pressure control.

Long-term use of phenoxybenzamine is not recommended (see PRECAUTIONS Carcinogenesis and Mutagenesis).

Storage

Store at 25°C (77°F); excursions permitted to 15°- 30°C (59°- 86°F) [See USP Controlled Room Temperature].

HOW SUPPLIED

Dibenzyline (phenoxybenzamine hydrochloride) capsules, 10 mg, in bottles of 100 (NDC 65197- 001-01).

** Available as Levophed® Bitartrate (brand of norepinephrine bitartrate) from Abbott Laboratories.

DATE OF ISSUANCE: MARCH 2008. Manufactured for WellSpring Pharmaceutical Corporation, Bradenton, FL 34202-4101, USA. By WellSpring Pharmaceutical Canada Corp. Oakville, Ontario L6H 1M5 Canada. Rev. 03/08. FDA rev date: 4/3/2008

Last reviewed on RxList: 5/14/2008
This monograph has been modified to include the generic and brand name in many instances.

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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