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Dienestrol

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Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

SIDE EFFECTS

(See WARNINGS regarding induction of neoplasia, adverse effects on the fetus, increased incidence of gall bladder disease, and adverse effects similar to those of oral contraceptives, including thromboembolism.) The following additional adverse reactions have been reported with estrogenic therapy, including oral contraceptives:

1. Genitourinary system.

    Increase in size of uterine fibromyomata.
    Vaginal candidiasis.
    Breakthrough bleeding, spotting, change in menstrual flow.
    Dysmenorrhea. Premenstrual-like syndrome.
    Amenorrhea during and after treatment.
    Change in cervical eversion and in degree of cervical secretion.
    Cystitis-like syndrome.

2. Breasts.

    Tenderness, enlargement, secretion.

3. Gastrointestinal.

4. Skin.

5. Eyes.

    Steepening of corneal curvature.
    Intolerance to contact lenses.

6. CNS.

7. Miscellaneous.

DRUG INTERACTIONS

Drug/ Laboratory Test Interactions

Certain endocrine and liver function tests may be affected by estrogen-containing oral contraceptives. The following similar changes may be expected with larger doses of estrogen:

  1. Increased sulfobromophthalein retention.
  2. Increased prothrombin and factors VII, VIII, IX, and X; decreased antithrombin 3; increased norepinephrine-induced platelet aggregability.
  3. Increased thyroid-binding globulin (TBG) leading to in-creased circulating total thyroid hormone; as measured by PBI, T4 by column, or T4 by radioimmunoassay. Free T3 resin uptake is decreased, reflecting the elevated TBG; free T4 concentration is unaltered.
  4. Impaired glucose tolerance.
  5. Decreased pregnanediol excretion.
  6. Reduced response to metyrapone test.
  7. Reduced serum folate concentration.
  8. Increased serum triglyceride and phospholipid concentration.

Last reviewed on RxList: 1/29/2005
This monograph has been modified to include the generic and brand name in many instances.

Additional Dienestrol Information

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