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Some adverse effects such as erythema, scaling, dryness, pruritus, and burning will occur in 10-40% of patients. Pruritus or burning immediately after application also occurs in approximately 20% of patients. The following additional adverse experiences were reported in approximately 1% or less of patients: skin irritation, burning/stinging, erythema, sunburn, and acne flares. These are most commonly seen during the first month of therapy and decrease in frequency and severity thereafter. All adverse effects with use of DIFFERIN® (adapalene gel) Gel during clinical trials were reversible upon discontinuation of therapy.

As DIFFERIN® (adapalene gel) Gel has the potential to produce local irritation in some patients, concomitant use of other potentially irritating topical products (medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, and products with high concentrations of alcohol, astringents, spices, or lime) should be approached with caution. Particular caution should be exercised in using preparations containing sulfur, resorcinol, or salicylic acid in combination with DIFFERIN® (adapalene gel) Gel. If these preparations have been used, it is advisable not to start therapy with DIFFERIN® (adapalene gel) Gel until the effects of such preparations in the skin have subsided.

Last reviewed on RxList: 9/19/2007
This monograph has been modified to include the generic and brand name in many instances.