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(digoxin) Tablets, USP
DIGITEK (digoxin) is one of the cardiac (or digitalis) glycosides, a closely related group of drugs having in common specific effects on the myocardium. These drugs are found in a number of plants. Digoxin is extracted from the leaves of Digitalis lanata. The term "digitalis" is used to designate the whole group of glycosides. The glycosides are composed of two portions: a sugar and a cardenolide (hence "glycosides").
Digoxin is described chemically as (3 β, 5 β, 12 β)-3-[(O-2, 6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl- (1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-card-20(22)-enolide. Its molecular formula is C41H64O14, its molecular weight is 780.94, and the structural formula shown:
Digoxin exists as odorless white crystals that melt with decomposition above 230°C. The drug is practically insoluble in water and in ether; slightly soluble in diluted (50%) alcohol and in chloroform; and freely soluble in pyridine.
DIGITEK (digoxin tablets) is supplied as 125-mcg (0.125-mg) or 250-mcg (0.25-mg) tablets for oral administration. Each tablet contains the labeled amount of digoxin USP and the following inactive ingredients: corn starch, croscarmellose sodium, microcrystalline cellulose, pregelatinized starch, lactose monohydrate and anhydrous lactose, silicon dioxide and stearic acid. In addition, the 125-mcg (0.125-mg) tablet contains D&C Yellow No. 10 Aluminum Lake.
What are the possible side effects of digoxin (Digitek, Lanoxicaps, Lanoxin)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- fast, slow, or uneven heart rate;
- bloody or black, tarry stools;
- blurred vision, yellowed vision; or
- confusion, hallucinations, unusual thoughts or behavior.
Less serious side effects may include:
- nausea, vomiting, diarrhea, loss of appetite;
- feeling weak or...
Last reviewed on RxList: 4/14/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Digitek Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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