September 3, 2015

Diindolylmethane

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Are there any interactions with medications?



Estrogens
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some of the effects of diindolylmethane might be similar to the hormone estrogen. Other effects of diindolylmethane might oppose the effects of estrogen. Taking large amounts of diindolylmethane might interfere with hormone replacement therapy.



Water pills (Diuretic drugs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Diindolylmethane might reduce the amount of sodium in the body. Some "water pills" can also decrease the amount of sodium in the body. Taking sodium-depleting "water pills" along with diindolylmethane might decrease sodium too much. Some "water pills" that can decrease sodium include acetazolamide (Diamox), chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDIURIL, Microzide), and others.



Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the liver. Diindolylmethane might increase how quickly the liver breaks down some medications. Taking diindolylmethane along with some medications that are changed by the liver can decrease the effectiveness of some medications. Before taking diindolylmethane, talk to your healthcare provider if you take any medications that are changed by the liver.

Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.

Dosing considerations for Diindolylmethane.

The appropriate dose of diindolylmethane depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for diindolylmethane. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.


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