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Dilacor XR is indicated for the treatment of hypertension. Diltiazem hydrochloride may be used alone or in combination with other antihypertensive medications, such as diuretics.
Dilacor XR is indicated for the management of chronic stable angina.
DOSAGE AND ADMINISTRATION
Hypertensive or anginal patients who are treated with other formulations of diltiazem can safely be switched to Dilacor XR capsules at the nearest equivalent total daily dose. Subsequent titration to higher or lower doses may, however, be necessary and should be initiated as clinically indicated.
Studies have shown a slight increase in the rate of absorption of Dilacor XR when ingested with a high-fat breakfast; therefore, administration in the morning on an empty stomach is recommended.
Patients should be cautioned that the Dilacor XR capsules should not be opened, chewed or crushed, and should be swallowed whole.
Hypertension: Dosages must be adjusted to each patient's needs, starting with 180 mg or 240 mg once daily. Based on the antihypertensive effect, the dose may be adjusted as needed. Individual patients, particularly ≥ 60 years of age, may respond to a lower dose of 120 mg. The usual dosage range studied in clinical trials was 180 mg to 480 mg once daily.
Current clinical experience with the 540 mg dose is limited; the dose may be increased to 540 mg with little or no increased risk of adverse reactions. Doses should not exceed 540 mg once daily.
While a dose of Dilacor XR given once daily may produce an antihypertensive effect similar to the same total daily dose given in divided doses, individual dose adjustment may be needed.
Angina: Dosages for the treatment of angina should be adjusted to each patient's needs, starting with a dose of 120 mg once daily, which may be titrated to doses of up to 480 mg once daily. When necessary, titration may be carried out over a 7 to 14 day period.
Concomitant Use with Other Cardiovascular Agents
Sublingual Nitroglycerin may be taken as required to abort acute anginal attacks during diltiazem hydrochloride therapy.
Prophylactic Nitrate Therapy – Diltiazem hydrochloride may be safely co-administered with short- and long-acting nitrates.
Antihypertensives – Diltiazem hydrochloride has an additive antihypertensive effect when used with other antihypertensive agents.
Therefore, the dosage of diltiazem hydrochloride or the concomitant antihypertensives may need to be adjusted when adding one to the other.
|120 mg||Bottles of 30||732-30||gold cap||Dilacor XR 120 mg|
|Bottles of 100||732-01||white body|
|Bottles of 1000||732-10|
|180 mg||Bottles of 30||733-30||orange cap||Dilacor XR 180 mg|
|Bottles of 100||733-01||white body|
|Unit Dose 100||733-44|
|Bottles of 1000||733-10|
|240 mg||Bottles of 30||734-30||brown cap||Dilacor XR 240 mg|
|Bottles of 100||734-01||white body|
|Unit Dose 100||734-44|
|Bottles of 1000||734-10|
National Stock Number
|120 mg||Bottles of 100||6505-01-365-8942|
|Bottles of 1000||6505-01-393-7440|
|180 mg||Bottles of 100||6505-01-355-3602|
|Bottles of 1000||6505-01-393-7319|
|240 mg||Bottles of 100||6505-01-355-3601|
|Bottles of 1000||6505-01-393-7437|
Store at Controlled Room Temperature: 20° to 25°C (68° to 77°F) [see USP].
Keep out of the reach of children
Manufactured for: WATSON Pharma, Inc. A Subsidiary of Watson Pharmaceuticals, Inc. Corona, CA 92880. Manufactured by: SkyePharma Production SAS St-Quentin-Fallavier Cedex, France. Revised: March 2011,This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 7/8/2011
Additional Dilacor XR Information
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