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Dilantin 125

Last reviewed on RxList: 11/28/2016
Dilantin 125 Side Effects Center

Last reviewed on RxList 02/22/2017

Dilantin-125 (phenytoin oral) Suspension is an anti-epileptic drug, also called an anticonvulsant used to control seizures. Dilantin-125 is not made to treat all types of seizures. Dilantin-125 is available in generic form. Common side effects of Dilantin-125 include:

  • headache,
  • nausea,
  • vomiting,
  • constipation,
  • dizziness,
  • drowsiness,
  • sleep problems (insomnia),
  • nervousness, or
  • swelling and bleeding of the gums.

Tell your doctor if you have unlikely but serious side effects of Dilantin-125 including:

  • unusual eye movements,
  • loss of balance or coordination,
  • slurred speech,
  • confusion,
  • muscle twitching,
  • double or blurred vision,
  • tingling of the hands or feet,
  • facial changes (e.g., swollen lips, butterfly-shaped rash around the nose or cheeks),
  • excessive hair growth,
  • increased thirst or urination,
  • unusual tiredness,
  • bone or joint pain, or
  • easily broken bones.

Dosage of Dilantin-125 is individualized. Patients who have received no previous treatment may be started on one teaspoonful (5 mL) of Dilantin-125 Suspension three times daily, and the dose is then adjusted to suit individual requirements. Dilantin-125 may interact with stomach acid reducers, sedatives, estrogen hormone replacement, phenothiazines, disulfiram, methylphenidate, sulfa drugs, carbamazepine, sucralfate, molindone, phenobarbital, valproic acid, divalproex sodium, steroids, antidepressants, antibiotics, digoxin, furosemide, and theophylline. Tell your doctor all medications and supplements you use. During pregnancy, Dilantin-125 should be used only if prescribed. It may harm a fetus. Untreated seizures are a serious condition that can harm both a pregnant woman and her fetus; do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, talk to your doctor. Since birth control pills, patches, implants, and injections may not work if taken with this medication, discuss birth control with your doctor. This drug passes into breast milk. Consult your doctor before breastfeeding. Abrupt withdrawal of this medication can cause status epilepticus.

Our Dilantin-125 (phenytoin oral) Suspension Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Dilantin 125 Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have a serious side effect such as:

  • fever, swollen glands, body aches, flu symptoms;
  • skin rash, easy bruising or bleeding, severe tingling, numbness, pain, muscle weakness;
  • upper stomach pain, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes);
  • chest pain, irregular heart rhythm, feeling short of breath;
  • confusion, nausea and vomiting, swelling, rapid weight gain, urinating less than usual or not at all;
  • new or worsening cough with fever, trouble breathing;
  • tremor (uncontrolled shaking), restless muscle movements in your eyes, tongue, jaw, or neck;
  • patchy skin color, red spots, or a butterfly shaped skin rash over your cheeks and nose (worsens in sunlight); or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • slurred speech, loss of balance or coordination;
  • swollen or tender gums; or
  • headache, dizziness, nervousness, or sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Dilantin 125 (Phenytoin Oral Suspension)

Dilantin 125 Professional Information

SIDE EFFECTS

Body As a Whole

Allergic reactions in the form of rash and rarely more serious forms (see Skin and Appendages paragraph below) and DRESS (see WARNINGS) have been observed. Anaphylaxis has also been reported.

There have also been reports of coarsening of facial features, systemic lupus erythematosus, periarteritis nodosa, and immunoglobulin abnormalities.

Nervous System

The most common adverse reactions encountered with phenytoin therapy are nervous system reactions and are usually dose-related. Reactions include nystagmus, ataxia, slurred speech, decreased coordination, somnolence, and mental confusion. Dizziness, vertigo, insomnia, transient nervousness, motor twitchings, paresthesias, and headaches have also been observed. There have also been rare reports of phenytoin-induced dyskinesias, including chorea, dystonia, tremor and asterixis, similar to those induced by phenothiazine and other neuroleptic drugs. Cerebellar atrophy has been reported, and appears more likely in settings of elevated phenytoin levels and/or long-term phenytoin use.

A predominantly sensory peripheral polyneuropathy has been observed in patients receiving long-term phenytoin therapy.

Digestive System

Acute hepatic failure, toxic hepatitis, liver damage, nausea, vomiting, constipation, enlargement of the lips, and gingival hyperplasia.

Skin and Appendages

Dermatological manifestations sometimes accompanied by fever have included scarlatiniform or morbilliform rashes. A morbilliform rash (measles-like) is the most common; other types of dermatitis are seen more rarely. Other more serious forms which may be fatal have included bullous, exfoliative or purpuric dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis (see WARNINGS section). There have also been reports of hypertrichosis.

Hematologic and Lymphatic System

Hematopoietic complications, some fatal, have occasionally been reported in association with administration of phenytoin. These have included thrombocytopenia, leukopenia, granulocytopenia, agranulocytosis, and pancytopenia with or without bone marrow suppression. While macrocytosis and megaloblastic anemia have occurred, these conditions usually respond to folic acid therapy. Lymphadenopathy including benign lymph node hyperplasia, pseudolymphoma, lymphoma, and Hodgkin’s disease have been reported (see WARNINGS section).

Special Senses

Altered taste sensation including metallic taste.

Urogenital

Peyronie’s disease

Read the entire FDA prescribing information for Dilantin 125 (Phenytoin Oral Suspension)

Related Resources for Dilantin 125

Read the Dilantin 125 User Reviews »

© Dilantin 125 Patient Information is supplied by Cerner Multum, Inc. and Dilantin 125 Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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