The local adverse reactions which were reported with
DIPROLENE Lotion (betamethasone dipropionate) during controlled clinical trials were as follows: erythema,
folliculitis, pruritus and vesiculation each occurring in less than 1 % of
patients.
The following additional local adverse reactions have been
reported with topical corticosteroids, and they may occur more frequently with
the use of occlusive dressings and higher potency corticosteroids.
These reactions are listed in an approximately decreasing
order of occurrence: burning, itching, irritation, dryness, folliculitis,
hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis,
allergic contact dermatitis, secondary infection, skin atrophy, striae and
miliaria.
Systemic absorption of topical corticosteroids has produced
reversible hypothalamic-pituitary-adrenal (HPA) axis suppression,
manifestations of Cushing's syndrome, hyperglycemia, and glucosuria in some patients.