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(Generic versions may still be available.)
Disalcid Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Disalcid (salsalate) is a non-steroidal anti-inflammatory drug (NSAID) in a group of drugs called salicylates used to reduce pain, swelling, and joint stiffness caused by arthritis. The brand name Disalcid is no longer available in the U.S. Generic versions may be available. Common side effects of Disalcid (salsalate) include upset stomach, heartburn, or mild dizziness.
The usual adult dosage of salsalate is 3000 mg daily, given in divided doses as: two doses of two 750 mg tablets; OR two doses of three 500 mg tablets/capsules; OR three doses of two 500 mg tablets/capsules. Salsalate may interact with acetazolamide, cyclosporine, lithium, methotrexate, pemetrexed, tenofovir, antidepressants, blood thinners, oral diabetes medications, diuretics (water pills), gout medications, heart or blood pressure medications, medication used to prevent blood clots, medicine to treat or prevent osteoporosis, sodium bicarbonate, potassium citrate, sodium citrate, citric acid, sodium citrate and potassium, seizure medications, or steroids. Tell your doctor all medications and supplements you use. During pregnancy, salsalate should be taken only if prescribed. It may be harmful to a fetus if the mother takes the medication during the last 3 months of pregnancy. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Salsalate can pass into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.
Our Disalcid (salsalate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Disalcid in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have a serious side effect such as:
- chest pain, severe dizziness, shortness of breath, slurred speech, problems with vision or balance;
- sudden numbness or weakness, especially on one side of the body;
- feeling like you might pass out;
- black, bloody, or tarry stools;
- coughing up blood or vomit that looks like coffee grounds;
- hearing problems, ringing in your ears;
- swelling in your hands or feet, rapid weight gain;
- fast or pounding heartbeats;
- easy bruising or bleeding, fever, chills, sore throat, flu symptoms;
- urinating more or less than usual;
- severe stomach pain, ongoing nausea or vomiting; or
- dark urine, jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
- upset stomach, heartburn; or
- mild dizziness.
Read the entire detailed patient monograph for Disalcid (Salsalate)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Disalcid FDA Prescribing Information: Side Effects
In two well-controlled clinical trials (n= 280 patients), the following reversible adverse experiences characteristic of salicylates were most commonly reported with DISALCID (salsalate) , listed in descending order of frequency: tinnitus, nausea, hearing impairment, rash, and vertigo. These common symptoms of salicylates, i.e., tinnitus or reversible hearing impairment, are often used as a guide to therapy.
Although cause-and-effect relationships have not been established, spontaneous reports over a ten-year period have included the following additional medically significant adverse experiences: abdominal pain, abnormal hepatic function, anaphylactic shock, angioedema, bronchospasm, decreased creatinine dearance, diarrhea, G.I. bleeding, hepatitis, hypotension, nephritis and urticaria.
DRUG ABUSE AND DEPENDENCE
Drug abuse and dependence have not been reported with DISALCID (salsalate) .
Read the entire FDA prescribing information for Disalcid (Salsalate)
Additional Disalcid Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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