Ditropan (Oxybutynin Tablets) Drug Information: Overdosage and Contraindications

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May 27, 2012

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Urinary Incontinence in Children »

Urinary incontinence in children facts

Urinary incontinence in children is very common.
Nighttime wetting (nocturnal enuresis) is more common than daytime wetting (diurnal enuresis).
Most urinary incontinence is nonorganic and resolves without intervention.
Persistent primary enuresis and secondary enuresis may require further medical evaluation.
Treatment for most cases of enuresis involves behavioral modification.
Bedwetting alarms are very effective.
Medications should be reserved for select children.
Less than 1% of all affected children have persistent incontinence into adulthood.

What is urinary incontinence?

Very simply stated, urinary incontinence is defined as the loss of complete control of the act of urination or the involuntary emptying of the bladder. It is also referred to as enuresis. It can be caused by any number of factors,...

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OVERDOSE

Treatment should be symptomatic and supportive. Activated charcoal as well as a cathartic may be administered.

Overdosage with oxybutynin chloride has been associated with anticholinergic effects including central nervous system excitation (e.g., restlessness, tremor, irritability, convulsions, delirium, hallucinations), flushing, fever, dehydration, cardiac arrhythmia, vomiting, and urinary retention. Other symptoms may include hypotension or hypertension, respiratory failure, paralysis, and coma.

Ingestion of 100 mg oxybutynin chloride in association with alcohol has been reported in a 13-year-old boy who experienced memory loss, and a 34-year-old woman who developed stupor, followed by disorientation and agitation on awakening, dilated pupils, dry skin, cardiac arrhythmia, and retention of urine. Both patients fully recovered with symptomatic treatment.

CONTRAINDICATIONS

DITROPAN® (oxybutynin chloride) is contraindicated in patients with urinary retention, gastric retention and other severe decreased gastrointestinal motility conditions, uncontrolled narrow-angle glaucoma and in patients who are at risk for these conditions.

DITROPAN is also contraindicated in patients who have demonstrated hypersensitivity to the drug substance or other components of the product.

Last reviewed on RxList: 4/2/2012
This monograph has been modified to include the generic and brand name in many instances.