"The U.S. Food and Drug Administration today approved Dotarem (gadoterate meglumine) for use in magnetic resonance imaging (MRI) of the brain, spine and associated tissues of patients ages 2 years and older.
Dotarem is a gadolinium-based"...
(Generic versions may still be available.)
Diucardin (hydroflumethiazide) is indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.
USAGE IN PREGNANCY
The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard. Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developed toxemia.
Edema during pregnancy may arise from pathological causes or from the physiologic and mechanical consequences of pregnancy. Thiazides are indicated in pregnancy when edema is due to pathologic causes just as they are in the absence of pregnancy (however, see " PRECAUTIONS PREGNANCY" below).
Dependent edema in pregnancy, resulting from restriction of venous return by the expanded uterus, is properly treated through elevation of the lower extremities and use of support hose. Use of diuretics to lower intravascular volume in this case is illogical and unnecessary. There is hypervolemia during normal pregnancy which is harmful to neither the fetus nor the mother (in absence of cardiovascular disease), but which is associated with edema, including generalized edema, in the majority of pregnant women. If this edema produces discomfort, increased recumbency will often provide relief. In rare instances, this edema may cause extreme discomfort which is not relieved by rest. In these cases, a short course of diuretics may provide relief and may be appropriate.
DOSAGE AND ADMINISTRATION
The average adult diuretic dose is 25 to 200 mg per day. The average adult antihypertensive dose is 50 to 100 mg per day.
Therapy should be individualized according to patient response. This therapy should be titrated to gain maximal response as well as the minimal dose possible to maintain that therapeutic response.
Diucardin (hydroflumethiazide) ® Each scored, white oval compressed tablet, inscribed "DIUCARDIN 50," contains 50 mg hydroflumethiazide, in bottles of 100 (NDC 0046-0702-81).
Store at room temperature (approximately 25° C)
Dispense in a well-closed container as defined in the USP
Caution: Federal law prohibits dispensing without prescription.
Ayerst Laboratories Inc.
A Wyeth-Ayerst Company
Philadelphia, PA 19101
Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.
Additional Diucardin Information
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