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Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Diucardin Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Diucardin (hydroflumethiazide) is a diuretic-antihypertensive drug used as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, corticosteroid and estrogen therapy, and forms of renal dysfunction such as: nephrotic syndrome, acute glomerulonephritis, and chronic renal failure. It is also used to manage hypertension either alone or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension. The brand name of this medication is discontinued, but generic versions may be available. Common side effects include low blood sodium or potassium levels, or an imbalance of sodium and potassium in the blood, high blood sugar, low blood pressure, sun sensitive skin, loss of appetite, nausea, vomiting, diarrhea, stomach cramps, and sexual problems.

The average adult diuretic dose is 25 to 200 mg per day. The average adult antihypertensive dose is 50 to 100 mg per day. Diucardin may interact with oral anticoagulants, antigout medications, other antihypertensive drugs, preanesthetic and anesthetic drugs, skeletal-muscle relaxants, amphotericin B, corticosteroids, corticotropin (ACTH), digitalis, colestipol, hypoglycemic, lithium, methenamine, nonsteroidal anti-inflammatory drugs (NSAIDs), norepinephrine, and tubocurarine. Tell your doctor all medications and supplements you use. During pregnancy, Diucardin should be used only if prescribed. Thiazides pass into breast milk. If use of the drug is deemed essential, the patient may consider stopping nursing. Consult your doctor before breastfeeding.

Our Diucardin (hydroflumethiazide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Diucardin FDA Prescribing Information: Side Effects
(Adverse Reactions)


The following adverse reactions have been observed, but there is not enough systematic collection of data to support an estimate of their frequency.


Anorexia, gastric irritation, nausea, vomiting, cramping, diarrhea, constipation, jaundice (intrahepatic cholestatic jaundice), pancreatitis, sialadenitis.


Dizziness, vertigo, paresthesias, headache, xanthopsia.


Leukopenia, agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia.


Orthostatic hypotension (may be aggravated by alcohol, barbiturates, or narcotics).


Purpura, photosensitivity, rash, urticaria, necrotizing angiitis (vasculitis, cutaneous vasculitis), fever, respiratory distress including pneumonitis, anaphylactic reactions.


Hyperglycemia, glycosuria, hyperuricemia, muscle spasm, weakness, restlessness, transient blurred vision.

Whenever adverse reactions are moderate or severe, thiazide dosage should be reduced or therapy withdrawn.

Read the entire FDA prescribing information for Diucardin (Hydroflumethiazide)


Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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