April 28, 2017
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(chlorothiazide) Oral Suspension


DIURIL (Chlorothiazide) is a diuretic and antihypertensive. It is 6-chloro-2 H-1,2,4-benzothiadiazine­7-sulfonamide 1,1-dioxide. Its empirical formula is C7H6ClN3O4S2 and its structural formula is:

 DIURIL® (Chlorothiazide) Structural Formula Illustration

It is a white, or practically white, crystalline powder with a molecular weight of 295.72, which is very slightly soluble in water, but readily soluble in dilute aqueous sodium hydroxide. It is soluble in urine to the extent of about 150 mg per 100 mL at pH 7.

DIURIL Oral Suspension contains 250 mg of chlorothiazide per 5 mL, alcohol 0.5 percent, with methylparaben 0.12 percent, propylparaben 0.02 percent, and benzoic acid 0.1 percent added as preservatives. The inactive ingredients are D&C Yellow 10, flavors, glycerin, purified water, sodium saccharin, sucrose and tragacanth.

What are the possible side effects of chlorothiazide (Diuril)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • nausea and vomiting with weakness, loss of appetite, headache, hallucinations, muscle pain, and/or seizure;
  • confusion, uneven heart rate, extreme thirst, leg discomfort, muscle weakness or limp feeling;
  • urinating more or less than usual or not at all;
  • easy bruising or...

Read All Potential Side Effects and See Pictures of Diuril »

What are the precautions when taking chlorothiazide (Diuril)?

Before taking chlorothiazide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe kidney disease (inability to make urine).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, untreated salt/mineral imbalance (e.g., imbalance of sodium, potassium, calcium, magnesium), loss of too much body water (dehydration), gout, lupus, certain recent nerve surgery...

Read All Potential Precautions of Diuril »

Last reviewed on RxList: 4/3/2017
This monograph has been modified to include the generic and brand name in many instances.

Diuril - User Reviews

Diuril User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Diuril sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Get tips on handling your hypertension.