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Diuril Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Diuril (chlorothiazide) is a thiazide diuretic (water pill) that treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or edema caused by taking steroids or estrogen. Diuril is also used to treat high blood pressure (hypertension). Diuril is available in generic form. Common side effects of Diuril include:
- spinning sensation,
- blurred vision,
- loss of appetite,
- stomach upset,
- stomach cramps,
- constipation, or
- muscle spasm as your body adjusts to Diuril.
Other side effects of Diuril include:
- decreased sexual ability,
- loss of interest in sex, or
- increased sensitivity to the sun.
Diuril may cause a loss of too much body water (dehydration) and salt/minerals. Tell your doctor if you have unlikely but serious symptoms of dehydration or mineral loss including very dry mouth, thirst, muscle cramps, weakness, fast or irregular heartbeat, nausea, vomiting, severe dizziness, unusual drowsiness, unusual decrease in the amount of urine, fainting, confusion, seizures.
The usual adult dosage of Diuril for edema is 500 mg to 1000 mg (10 mL to 20 mL) once or twice a day. The usual adult starting dosage for hypertension is 500 mg or 1000 mg (10 mL to 20 mL) a day as a single or divided dose. Pediatric dose is determined by the child's weight. Diuril may interact with other medicines that cause lightheadedness (i.e., cold or allergy medicine, narcotics, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety), lithium, digoxin, cholestyramine, colestipol, steroids, other blood pressure medications, aspirin, NSAIDs (nonsteroidal anti-inflammatory drugs), insulin or oral diabetes medicines. Diuril should be used only when prescribed during pregnancy. This drug passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breastfeeding.
Our Diuril (chlorothiazide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Diuril in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:
- nausea and vomiting with weakness, loss of appetite, headache, hallucinations, muscle pain, and/or seizure;
- confusion, uneven heart rate, extreme thirst, leg discomfort, muscle weakness or limp feeling;
- urinating more or less than usual or not at all;
- easy bruising or bleeding;
- numbness or tingly feeling;
- fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
- jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
- dizziness, spinning sensation;
- diarrhea, constipation, stomach cramps;
- muscle spasm;
- loss of interest in sex; or
- blurred vision.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Diuril (Chlorothiazide)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Diuril Overview - Patient Information: Side Effects
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
This medication may cause a loss of too much body water (dehydration) and salt/minerals. Tell your doctor immediately if you have any of these unlikely but serious symptoms of dehydration or mineral loss: very dry mouth, thirst, muscle cramps, weakness, fast/irregular heartbeat, nausea, vomiting, severe dizziness, unusual drowsiness, unusual decrease in the amount of urine, fainting, confusion, seizures.
Tell your doctor immediately if any of these unlikely but serious side effects occur: numbness/tingling of the arms/legs, joint pain (e.g., big toe pain).
Tell your doctor immediately if any of these rare but very serious side effects occur: signs of infection (e.g., fever, persistent sore throat), easy bruising/bleeding, stomach/abdominal pain, persistent nausea/vomiting, unusual/persistent tiredness, yellowing eyes/skin, dark urine, unusual change in the amount of urine (not including the normal increase in urine when you first start this drug).
Get medical help right away if you have any very serious side effects, including: decrease in vision, eye pain.
A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Diuril (Chlorothiazide)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Diuril FDA Prescribing Information: Side Effects
The following adverse reactions have been reported and, within each category, are listed in order of decreasing severity.
Body as a Whole: Weakness.
Hematologic: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia. Hypersensitivity: Anaphylactic reactions, necrotizing angiitis (vasculitis and cutaneous vasculitis), respiratory distress including pneumonitis and pulmonary edema, photosensitivity, fever, urticaria, rash, purpura.
Nervous System/Psychiatric: Vertigo, paresthesias, dizziness, headache, restlessness.
Whenever adverse reactions are moderate or severe, thiazide dosage should be reduced or therapy withdrawn.
Read the entire FDA prescribing information for Diuril (Chlorothiazide)
Additional Diuril Information
Diuril - User Reviews
Diuril User Reviews
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Get tips on handling your hypertension.