"The U.S. Food and Drug Administration today approved Osphena (ospemifene) to treat women experiencing moderate to severe dyspareunia (pain during sexual intercourse), a symptom of vulvar and vaginal atrophy due to menopause.
Divigel Patient Information including If I Miss a Dose
In this Article
- What is estradiol topical (Divigel)?
- What are the possible side effects of estradiol topical?
- What is the most important information I should know about estradiol topical?
- What should I discuss with my health care provider before using estradiol topical?
- How should I use estradiol topical?
- What happens if I miss a dose?
- What happens if I overdose?
- What should I avoid while using estradiol topical?
- What other drugs will affect estradiol topical?
- Where can I get more information?
What happens if I miss a dose?
If you are less than 12 hours late in using your medicine, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include nausea, vomiting, stomach pain, breast tenderness, drowsiness, and vaginal bleeding.
What should I avoid while using estradiol topical?
Do not apply sunscreen to your skin at the same time you apply estradiol topical.
Avoid getting this medication in your eyes. If this does happen, rinse with water.
Grapefruit and grapefruit juice may interact with estradiol and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.
What other drugs will affect estradiol topical?
Tell your doctor about all other medications you use, especially:
- St. John's wort;
- a blood thinner such as warfarin (Coumadin, Jantoven);
- ritonavir (Norvir, Kaletra);
- carbamazepine (Carbatrol, Equetro, Tegretol) or phenobarbital (Luminal, Solfoton);
- an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), or rifampin (Rifadin, Rifater, Rifamate, Rimactane).
- an antifungal medication such as ketoconazole (Extina, Ketozole, Nizoral, Xolegal) or itraconazole (Sporanox).
This list is not complete and other drugs may interact with estradiol topical. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Where can I get more information?
Your pharmacist can provide more information about estradiol topical.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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