Dolobid

Indications
Dosage
How Supplied

INDICATIONS

Carefully consider the potential benefits and risks of DOLOBID (diflunisal) and other treatment options before deciding to use DOLOBID (diflunisal) . Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS).

DOLOBID (diflunisal) is indicated for acute or long-term use for symptomatic treatment of the following:

  1. Mild to moderate pain
  2. Osteoarthritis
  3. Rheumatoid arthritis

DOSAGE AND ADMINISTRATION

Carefully consider the potential benefits and risks of DOLOBID (diflunisal) and other treatment options before deciding to use DOLOBID (diflunisal) . Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS).

After observing the response to initial therapy with DOLOBID (diflunisal) , the dose and frequency should be adjusted to suit an individual patient's needs.

Concentration-dependent pharmacokinetics prevail when DOLOBID (diflunisal) is administered; a doubling of dosage produces a greater than doubling of drug accumulation. The effect becomes more apparent with repetitive doses.

For mild to moderate pain, an initial dose of 1000 mg followed by 500 mg every 12 hours is recommended for most patients. Following the initial dose, some patients may require 500 mg every 8 hours.

A lower dosage may be appropriate depending on such factors as pain severity, patient response, weight, or advanced age; for example, 500 mg initially, followed by 250 mg every 8-12 hours.

For osteoarthritis and rheumatoid arthritis, the suggested dosage range is 500 mg to 1000 mg daily in two divided doses. The dosage of DOLOBID (diflunisal) may be increased or decreased according to patient response.

Maintenance doses higher than 1500 mg a day are not recommended.

Tablets should be swallowed whole, not crushed or chewed.

HOW SUPPLIED

Tablets DOLOBID (diflunisal) are capsule-shaped, film-coated tablets supplied as follows:

No. 3390 250 mg peach colored, coded DOLOBID (diflunisal) on one side and MSD 675 on the other.

NDC 0006-0675-61 unit of use bottles of 60
(6505-01-164-0501, 250 mg 60's).

No. 3392 500 mg orange colored, coded DOLOBID (diflunisal) on one side and MSD 697 on the other.

NDC 0006-0697-61 unit of use bottles of 60
(6505-01-144-9724, 500 mg 60's).

Distributed by: MERCK & Co. Inc, Whitehouse Station, NJ 08889, USA, Issued January 2007. FDA revision date: 3/16/2007

Last reviewed on RxList: 2/27/2008
This monograph has been modified to include the generic and brand name in many instances.

Indications
Dosage
How Supplied
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