In this Article

• What is diflunisal (Dolobid)?
• What are the possible side effects of diflunisal (Dolobid)?
• What is the most important information I should know about diflunisal (Dolobid)?
• What should I discuss with my healthcare provider before taking diflunisal (Dolobid)?
• How should I take diflunisal (Dolobid)?
• What happens if I miss a dose (Dolobid)?
• What happens if I overdose (Dolobid)?
• What should I avoid while taking diflunisal (Dolobid)?
• What other drugs will affect diflunisal (Dolobid)?
• Where can I get more information?

What should I discuss with my healthcare provider before taking diflunisal (Dolobid)?

This medicine may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term.

This medicine may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking diflunisal, especially in older adults.

Do not use this medication if you are allergic to diflunisal, or if you have a history of allergic reaction to aspirin or other NSAIDs. Do not use diflunisal just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

If you have any of these other conditions, you may need a diflunisal dose adjustment or special tests:

• a history of heart attack, stroke, or blood clot;
• heart disease, congestive heart failure, high blood pressure;
• a history of stomach ulcers or bleeding;
• liver or kidney disease;
• asthma;
• polyps in your nose;
• a bleeding or blood clotting disorder; or
• if you smoke.

FDA pregnancy category C. It is not known whether diflunisal is harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking diflunisal during the last 3 months of pregnancy may result in birth defects. Do not take diflunisal during pregnancy unless your doctor has told you to.

Diflunisal can pass into breast milk and could cause harm to a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not give this medicine to a child younger than 12 years old without the advice of a doctor.

How should I take diflunisal (Dolobid)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Diflunisal is usually taken every 8 to 12 hours. Follow your doctor's instructions.

If you use this medication long-term, your blood may need to be tested often. Your blood pressure may also need to be checked. Visit your doctor regularly.

This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using diflunisal.

Store at room temperature away from moisture and heat.