"The U.S. Food and Drug Administration today approved Viberzi (eluxadoline) and Xifaxan (rifaximin), two new treatments, manufactured by two different companies, for irritable bowel syndrome with diarrhea (IBS-D) in adult men and women.
Diarrhea may be an early symptom of incomplete intestinal obstruction, especially in patients with ileostomy or colostomy. In this instance treatment with this drug would be inappropriate and possibly harmful.
Donnatal Extentabs® (belladonna alkaloids, phenobarbital) may produce drowsiness or blurred vision. The patient should be warned, should these occur, not to engage in activities requiring mental alertness, such as operating a motor vehicle or other machinery, and not to perform hazardous work.
Phenobarbital may decrease the effect of anticoagulants and necessitate larger doses of the anticoagulant for optimal effect. When phenobarbital is discontinued, the dose of the anticoagulant may have to be decreased.
Phenobarbital may be habit forming and should not be administered to individuals known to be addiction prone or to those with a history of physical and/or psychological dependence upon drugs.
Use with caution in patients with: autonomic neuropathy, hepatic or renal disease, hyperthyroidism, coronary heart disease, congestive heart failure, cardiac arrhythmias, tachycardia, and hypertension.
Theoretically, with overdosage, a curare-like action may occur.
Carcinogenesis, mutagenesis: Long-term studies in animals have not been performed to evaluate c arcinogenic potential.
Pregnancy Category C: Animal reproduction studies have not been conducted with Donnatal Extentabs® (belladonna alkaloids, phenobarbital) . It is not known whether Donnatal Extentabs® (belladonna alkaloids, phenobarbital) can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Donnatal Extentabs® (belladonna alkaloids, phenobarbital) should be given to a pregnant woman only if clearly needed.
Nursing mothers: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Donnatal Extentabs® (belladonna alkaloids, phenobarbital) is administered to a nursing mother.
Last reviewed on RxList: 4/23/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Donnatal Extentabs Information
Donnatal Extentabs - User Reviews
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