"The U.S. Food and Drug Administration today approved Dotarem (gadoterate meglumine) for use in magnetic resonance imaging (MRI) of the brain, spine and associated tissues of patients ages 2 years and older.
Dotarem is a gadolinium-based"...
(Generic versions may still be available.)
Larodopa is indicated in the treatment of idiopathic Parkinson's disease (Paralysis Agitans), postencephalitic parkinsonism, symptomatic parkinsonism which may follow injury to the nervous system by carbon monoxide intoxication, and manganese intoxication. It is indicated in those elderly patients believed to develop parkinsonism in association with cerebral arteriosclerosis.
DOSAGE AND ADMINISTRATION
The optimal daily dose of Larodopa, i.e., the dose producing maximal improvement with tolerated side effects, must be determined and carefully titrated for each individual patient. The usual initial dosage is 0.5 g to 1 g daily, divided into two or more doses with food.
The total daily dosage is then increased gradually in increments not more than 0.75 g every 3 to 7 days as tolerated. The usual optimal therapeutic dosage should not exceed 8 g. The exceptional patient may carefully be given more than 8 g as required. In some patients, a significant therapeutic response may not be obtained until 6 months of treatment.
In the event general anesthesia is required, Larodopa therapy may be continued as long as the patient is able to take fluids and medication by mouth. If therapy is temporarily interrupted, the usual daily dosage may be administered as soon as the patient is able to take oral medication. Whenever therapy has been interrupted for longer periods, dosage should again be adjusted gradually; however, in many cases the patient can be rapidly titrated to his/her previous therapeutic dosage.
Tablets, pink, scored, each containing levodopa 0.1 g (NDC 0004-0072-01), 0.25 g (NDC 0004-0057-01) or 0.5 g (NDC 0004-0056-01)-bottles of 100.
Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.
Additional Dopar Information
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