"The US Food and Drug Administration (FDA) today approved asfotase alfa (Strensiq, Alexion Pharmaceuticals) as the first-ever therapy for patients who develop hypophosphatasia, a rare metabolic bone disorder, in childhood.
(Generic versions may still be available.)
Dopar Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Dopar (levodopa) is an antiparkinson agent, and is a medicine that the brain converts to dopamine. Dopar is often used with carbidopa to control symptoms of Parkinson's disease and may be used at all stages of the disease. The brand name Dopar is no longer available in the U.S. Generic versions may be available. Common side effects of Dopar (levodopa) include stomach pain, nausea, vomiting, diarrhea, constipation, dry mouth, anxiety, nervousness, confusion, nightmare, or twitching.
The optimal daily dose of Dopar is individualized for each patient. Dopar should be administered cautiously to patients with severe cardiovascular or pulmonary disease, bronchial asthma, renal, hepatic or endocrine disease. Dopar may interact with other drugs. Tell your doctor all medications you use. If you are pregnant, only take Dopar if the potential benefit outweighs the potential risk to the fetus. Consult your doctor before breastfeeding.
Our Dopar (levodopa) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Dopar FDA Prescribing Information: Side Effects
The most serious adverse reactions associated with the administration of Larodopa having frequent occurrences are: adventitious movements such as choreiform and/or dystonic movements. Other serious adverse reactions with a lower incidence are: cardiac irregularities and/or palpitations, orthostatic hypotensive episodes, bradykinetic episodes (the "on-off" phenomena), mental changes including paranoid ideation and psychotic episodes, depression with or without the development of suicidal tendencies, dementia and urinary retention.
Rarely, gastrointestinal bleeding, development of duodenal ulcer, hypertension, phlebitis, hemolytic anemia, agranulocytosis and convulsions have been observed. (The causal relationship between convulsions and Larodopa has not been established.)
Adverse reactions of a less serious nature having a relatively frequent occurrence are the following: anorexia, nausea and vomiting with or without abdominal pain and distress, dry mouth, dysphagia, sialorrhea, ataxia, increased hand tremor, headache, dizziness, numbness, weakness and faintness, bruxism, confusion, insomnia, nightmares, hallucinations and delusions, agitation and anxiety, malaise, fatigue and euphoria. Occurring with a lesser order of frequency are the following: muscle twitching and blepharospasm (which may be taken as an early sign of overdosage; consideration of dosage reduction may be made at this time), trismus, burning sensation of the tongue, bitter taste, diarrhea, constipation, flatulence, flushing, skin rash, increased sweating, bizarre breathing patterns, urinary incontinence, diplopia, blurred vision, dilated pupils, hot flashes, weight gain or loss, dark sweat and/or urine.
Elevations of blood urea nitrogen, SGOT, SGPT, LDH, bilirubin, alkaline phosphatase or protein-bound iodine have been reported; and the significance of this is not known. Occasional reductions in WBC, hemoglobin and hematocrit have been noted.
Leukopenia has occurred and requires cessation, at least temporarily, of Larodopa administration. The Coombs' test has occasionally become positive during extended therapy. Elevations of uric acid have been noted when colorimetric method was used but not when uricase method was used.
Read the entire FDA prescribing information for Dopar (Levodopa)
Additional Dopar Information
- Dopar Drug Interactions Center: levodopa oral
- Dopar Side Effects Center
- Dopar FDA Approved Prescribing Information including Dosage
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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