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Dopram Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 1/3/2016

Dopram (doxapram hydrochloride) Injection is a respiratory stimulant used to treat respiratory insufficiency due to drug overdose, surgery, or chronic pulmonary disease. Dopram is available in generic form. Common side effects of Dopram include flushing, sweating, headache, dizziness, cough, chest pain, nausea, vomiting, diarrhea, difficulty breathing, high blood pressure (hypertension), difficulty urinating, and muscle spasms.

The recommended dosage of Dopram is 0.5 - 1 mg/kg given every 5 minutes, not to exceed 2 mg/kg. General anesthesia, aminophylline, and theophylline may interact with Dopram. Before taking Dopram tell your doctor if you have impaired hepatic or renal function. If you are pregnant only use Dopram if clearly needed. Exercise caution if you receive Dopram and are breastfeeding.

Our Dopram (doxapram hydrochloride) Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Dopram FDA Prescribing Information: Side Effects
(Adverse Reactions)


Adverse reactions reported coincident with the administration of DOPRAM (doxapram hydrochloride, USP) include:

Central and Autonomic Nervous Systems

Pyrexia, flushing, sweating; pruritus and paresthesia, such as a feeling of warmth, burning, or hot sensation, especially in the area of genitalia and perineum; apprehension, disorientation, pupillary dilatation, hallucinations, headache, dizziness, hyperactivity, involuntary movements, muscle spasticity, muscle fasciculations, increased deep tendon reflexes, clonus, bilateral Babinski, and convulsions.


Dyspnea, cough, hyperventilation, tachypnea, laryngospasm, bronchospasm, hiccough, and rebound hypoventilation.


Phlebitis, variations in heart rate, lowered T-waves, arrhythmias (including ventricular tachycardia and ventricular fibrillation), chest pain, tightness in chest. A mild to moderate increase in blood pressure is commonly noted and may be of concern in patients with severe cardiovascular diseases.


Nausea, vomiting, diarrhea, desire to defecate.


Stimulation of urinary bladder with spontaneous voiding; urinary retention. Elevation of BUN and albuminuria.

Hemic and Lymphatic

Hemolysis with rapid infusion. A decrease in hemoglobin, hematocrit, or red blood cell count has been observed in postoperative patients. In the presence of pre-existing leukopenia, a further decrease in WBC has been observed following anesthesia and treatment with doxapram hydrochloride.

Read the entire FDA prescribing information for Dopram (Doxapram)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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