Doribax (Doripenem for Injection) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 27, 2012

Doribax

Streptococcal Infections »

Group A streptococcal infections facts

Group A streptococci (GAS) are defined gram-positive coccal-shaped bacteria that produce beta-hemolysis (lysis of red blood cells producing clear or transparent areas in special growth media) and appear usually as a chain of two or more bacteria and have molecules on their surface known as Lancefield group A antigens.
Group A Streptococcus (GAS) organisms are usually spread by direct human-to-human transfer. Occasionally, they can be spread by droplets or by a person touching items recently handled by an infected individual (also termed fomites).
GAS can cause a wide range of diseases, but most notably, strep throat; other diseases (or complications) include scarlet fever, rheumatic fever, kidney damage, skin and wound infections and occasionally, necrotizing fasciitis and toxic shock syndrome...

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Doribax

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DORIBAX
(doripenem)

DRUG DESCRIPTION

DORIBAX®, doripenem monohydrate for injection vials contain 500 mg of doripenem on an anhydrous basis, a white to slightly-yellowish off-white sterile crystalline powder. All references to doripenem activity are expressed in terms of the active doripenem moiety. The powder is constituted for intravenous infusion. The pH of the infusion solution is between 4.5 and 5.5.

DORIBAX® is not formulated with any inactive ingredients.

DORIBAX® (doripenem monohydrate) is a synthetic broad-spectrum carbapenem antibiotic structurally related to beta-lactam antibiotics. The chemical name for doripenem monohydrate is (4R,5S,6S)-3-[((3S,5S)-5-[[(aminosulfonyl)amino]methyl]-3pyrrolidinyl)thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene2-carboxylic acid monohydrate.

Its molecular weight is 438.52, and its chemical structure is:

DORIBAX (doripenem) Structural Formula Illustration

What are the possible side effects of doripenem (Doribax)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

diarrhea that is watery or bloody;
trouble breathing;
pale skin, easy bruising or bleeding;
seizure (convulsions); or
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash.

Less serious side effects may...

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What are the precautions when taking doripenem for injection (Doribax)?

Before using doripenem, tell your doctor or pharmacist if you are allergic to it; or to carbapenems (e.g., meropenem), penicillins or cephalosporins; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, seizures.

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, older adults may be at greater risk for side effects while using this drug.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known...

Read All Potential Precautions of Doribax »

Last reviewed on RxList: 2/16/2012
This monograph has been modified to include the generic and brand name in many instances.