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Doribax

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Doribax

DORIBAX®
(doripenem)  for Injection

DRUG DESCRIPTION

DORIBAX®, doripenem monohydrate for injection vials contain 500 mg of doripenem on an anhydrous basis, a white to slightly-yellowish off-white sterile crystalline powder. All references to doripenem activity are expressed in terms of the active doripenem moiety. The powder is constituted for intravenous infusion. The pH of the infusion solution is between 4.5 and 5.5.

DORIBAX® is not formulated with any inactive ingredients.

DORIBAX® (doripenem monohydrate) is a synthetic broad-spectrum carbapenem antibiotic structurally related to beta-lactam antibiotics. The chemical name for doripenem monohydrate is (4R,5S,6S)-3-[((3S,5S)-5-[[(aminosulfonyl)amino]methyl]-3-pyrrolidinyl) thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate.

Its molecular weight is 438.52, and its chemical structure is:

DORIBAX® (doripenem) Structural Formula Illustration

What are the possible side effects of doripenem (Doribax)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • diarrhea that is watery or bloody; or
  • severe itching or skin rash.

Other common side effects may include:

  • headache;
  • diarrhea, nausea;
  • vaginal itching or discharge;
  • mild rash; or
  • pain, swelling, or redness where the medicine was injected.

This is not a complete list of side effects and others may occur....

Read All Potential Side Effects and See Pictures of Doribax »

What are the precautions when taking doripenem for injection (Doribax)?

Before using doripenem, tell your doctor or pharmacist if you are allergic to it; or to carbapenems (e.g., meropenem), penicillins or cephalosporins; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, seizures, stroke.

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, older adults may be at greater risk for side effects while using this drug.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not...

Read All Potential Precautions of Doribax »

Last reviewed on RxList: 1/30/2014
This monograph has been modified to include the generic and brand name in many instances.

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Doribax - User Reviews

Doribax User Reviews

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Here is a collection of user reviews for the medication Doribax sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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