"Current clinical guidelines for identifying methicillin-resistant Staphylococcus aureus (MRSA) at hospital admission are resulting in 30 times more patients with pneumonia being treated with anti-MRSA drugs than theoretically necessary bec"...
(doripenem) for Injection
DORIBAX®, doripenem monohydrate for injection vials contain 500 mg of doripenem on an anhydrous basis, a white to slightly-yellowish off-white sterile crystalline powder. All references to doripenem activity are expressed in terms of the active doripenem moiety. The powder is constituted for intravenous infusion. The pH of the infusion solution is between 4.5 and 5.5.
DORIBAX® is not formulated with any inactive ingredients.
DORIBAX® (doripenem monohydrate) is a synthetic broad-spectrum carbapenem antibiotic structurally related to beta-lactam antibiotics. The chemical name for doripenem monohydrate is (4R,5S,6S)-3-[((3S,5S)-5-[[(aminosulfonyl)amino]methyl]-3-pyrrolidinyl) thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate. Its molecular weight is 438.52, and its chemical structure is:
What are the possible side effects of doripenem (Doribax)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- diarrhea that is watery or bloody; or
- severe itching or skin rash.
Other common side effects may include:
- diarrhea, nausea;
- vaginal itching or discharge;
- mild rash; or
- pain, swelling, or redness where the medicine was injected.
This is not a complete list of side effects and others may occur....
What are the precautions when taking doripenem for injection (Doribax)?
Before using doripenem, tell your doctor or pharmacist if you are allergic to it; or to carbapenems (e.g., meropenem), penicillins or cephalosporins; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, seizures, stroke.
Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, older adults may be at greater risk for side effects while using this drug.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is not...
Last reviewed on RxList: 8/27/2015
This monograph has been modified to include the generic and brand name in many instances.
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