Doryx (Doxycycline Hyclate) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Doryx

Plague »

Plague facts

A bacterium, Yersinia pestis, causes the disease in animals and humans.
Plague is a disease that is transmitted from infected animals, usually by fleas, to humans. Plague then may be transmitted from humans to others by direct contact or by touching or breathing droplets that contain the bacterium, Yersinia pestis. Untreated plague causes much suffering and deaths in humans.
Symptoms of plague vary and are grouped into three types:

Bubonic: The lymph nodes become swollen, tender, and are termed buboes. The patient may also develop fever, chills, and weakness.
Septicemic: In general, septicemic plague patients do not develop buboes. Instead symptoms may include fever, chills, weakness, bleeding under the skin, abdominal pain, and septic shock with low blood pressure.
Pneumonic: Shortness of breath, cough (sometimes with bloody sputum), and chest pain quickly de...

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Doryx

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DORYX®
(doxycycline hyclate) Delayed-Release Tablets, USP, 75 mg, 100 mg and 150 mg for Oral use.

DRUG DESCRIPTION

DORYX (Doxycycline Hyclate Delayed-Release Tablets, USP), for oral administration, contain specially coated pellets of doxycycline hyclate, a broad-spectrum antibiotic synthetically derived from oxytetracycline, in a delayed-release formulation for oral administration.

The structural formula for doxycycline hyclate is:

DORYX®
(Doxycycline Hyclate) Structural Formula Illustration

with a molecular formula of C₂₂H₂₄N₂O₈, HCl, ½ C₂H₆O, ½ H₂O and a molecular weight of 512.9. The chemical designation for doxycycline hyclate is [4S(4aR,5S,5aR,6R,12aS)] -4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6methyl- 1,11-deoxonapthtacene-2-carboxamide monohydrochloride, compound with ethyl alcohol (2:1), monohydrate. Doxycycline hyclate is a yellow crystalline powder soluble in water and in solutions of alkali hydroxides and carbonates. Doxycycline has a high degree of lipid solubility and a low affinity for calcium binding. It is highly stable in normal human serum. Doxycycline will not degrade into an epianhydro form. Inert ingredients in the tablet formulation are: lactose monohydrate; microcrystalline cellulose; sodium lauryl sulfate; sodium chloride; talc; anhydrous lactose; corn starch; crospovidone; magnesium stearate; cellulosic polymer coating.

What are the possible side effects of doxycycline?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using doxycycline and call your doctor at once if you have any of these serious side effects:

severe headache, dizziness, blurred vision;
fever, chills, body aches, flu symptoms;
severe blistering, peeling, and red skin rash;
urinating less than usual or not at all;
pale or yellowed skin, dark colored urine, fever, confusion or...

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What are the precautions when taking doxycycline hyclate (Doryx)?

Before taking doxycycline, tell your doctor or pharmacist if you are allergic to it; or to other tetracyclines (such as minocycline); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: trouble swallowing, esophagus problems (such as hiatal hernia or reflux/heartburn).

Before having surgery, tell your doctor or dentist that you are taking this medication.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.

This drug...

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Last reviewed on RxList: 4/17/2012
This monograph has been modified to include the generic and brand name in many instances.