Drug interactions with ado-trastuzumab emtansine iv and itraconazole oral

ado-trastuzumab emtansine iv brand names and other generic formulations include:

Kadcyla IV

All generic drug interactions for ado-trastuzumab emtansine iv (lists will include brand and generic names):

itraconazole oral brand names and other generic formulations include:

Onmel Oral, Sporanox Oral, Sporanox Pulsepak Oral

All generic drug interactions for itraconazole oral (lists will include brand and generic names):
Serious - Use AlternativePotential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

ado-trastuzumab emtansine iv and itraconazole oral

ado-trastuzumab emtansine iv increases levels of itraconazole oral by altering drug metabolism. There may be an increased risk of side effects.

Patient Drug Interactions Source: RxList
© 2014 RxList, Inc.
Serious - Use AlternativePossible serious or life-threatening interaction. Monitor closely. Use alternatives if available.

ado-trastuzumab emtansine iv and itraconazole oral

ado-trastuzumab emtansine iv increases levels of itraconazole oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. DM1, the cytotoxic component, is metabolized mainly by CYP3A4; strong CYP3A4 inhibitors may increase DM1 exposure and toxicity

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2014 WebMD, LLC.
Serious - Use AlternativePotential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

itraconazole oral and ado-trastuzumab emtansine iv

itraconazole oral increases levels of ado-trastuzumab emtansine iv by altering drug metabolism. There may be an increased risk of side effects.

Patient Drug Interactions Source: RxList
© 2014 RxList, Inc.
Serious - Use AlternativePossible serious or life-threatening interaction. Monitor closely. Use alternatives if available.

itraconazole oral and ado-trastuzumab emtansine iv

itraconazole oral increases levels of ado-trastuzumab emtansine iv by affecting hepatic/intestinal enzyme CYP3A4 metabolism. DM1, the cytotoxic component, is metabolized mainly by CYP3A4; strong CYP3A4 inhibitors may increase DM1 exposure and toxicity

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2014 WebMD, LLC.

Check for more interactions with the Drug Interaction Checker

Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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