Drug interactions with cyclosporine modified oral and sirolimus oral

cyclosporine modified oral brand names and other generic formulations include:

Gengraf Oral, Neoral Oral, SangCya Oral

All generic drug interactions for cyclosporine modified oral (lists will include brand and generic names):

sirolimus oral brand names and other generic formulations include:

Rapamune Oral

All generic drug interactions for sirolimus oral (lists will include brand and generic names):
Significant - Monitor CloselySignificant interaction possible (monitoring by your doctor required)

cyclosporine modified oral and sirolimus oral

cyclosporine modified oral will increase the level or effect of sirolimus oral by altering drug metabolism. Taking these drugs together significantly increases sirolimus levels; minimize by taking sirolimus 4 hours after cyclosporine.

Patient Drug Interactions Source: RxList
© 2014 RxList, Inc.
Significant - Monitor CloselySignificant interaction possible, monitor closely.

cyclosporine modified oral and sirolimus oral

cyclosporine modified oral will increase the level or effect of sirolimus oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Simultaneous coadministration significantly increases sirolimus levels; this is minimized by administering sirolimus 4 hr after cyclosporine

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2014 WebMD, LLC.
Significant - Monitor CloselyPotential for significant interaction (monitoring by your doctor is likely required)

sirolimus oral and cyclosporine modified oral

sirolimus oral increases toxicity of cyclosporine modified oral by toxicity to the kidney that decreases urine formation or impairs hearing. Combination may increase side effects when sirolimus used in combination with full-dose cyclosporine; this effect is often reversible with cyclosporine dose reduction.

Patient Drug Interactions Source: RxList
© 2014 RxList, Inc.
Significant - Monitor CloselyPotential for dangerous interaction. Use with caution and monitor closely.

sirolimus oral and cyclosporine modified oral

sirolimus oral increases toxicity of cyclosporine modified oral by nephrotoxicity and/or ototoxicity. Elevations in serum creatinine, hemolytic uremic syndrome, TTP, and microangiopathy were observed when sirolimus used in combination with full-dose cyclosporine; this effect is often reversible with cyclosporine dose reduction

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2014 WebMD, LLC.

Check for more interactions with the Drug Interaction Checker

Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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