Drug interactions with dexamethasone sodium phosphate iv and ivacaftor oral

dexamethasone sodium phosphate iv brand names and other generic formulations include:

Decadron Phosphate IV

All generic drug interactions for dexamethasone sodium phosphate iv (lists will include brand and generic names):

ivacaftor oral brand names and other generic formulations include:

Kalydeco Oral

All generic drug interactions for ivacaftor oral (lists will include brand and generic names):
Serious - Use AlternativePotential for serious interaction; regular monitoring by your doctor required

dexamethasone sodium phosphate iv and ivacaftor oral

dexamethasone sodium phosphate iv decreases levels of ivacaftor oral by altering drug metabolism. Blood levels of ivacaftor may be reduced by 9 fold.

Patient Drug Interactions Source: RxList
© 2014 RxList, Inc.
Serious - Use AlternativeHigh likelihood serious or life-threatening interaction. Contraindicated unless benefits outweigh risks and no alternatives available.

dexamethasone sodium phosphate iv and ivacaftor oral

dexamethasone sodium phosphate iv decreases levels of ivacaftor oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid coadministration with strong CYP3A4 inducers; systemic exposure of ivacaftor substantially reduced (ie, ~9-fold)

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2014 WebMD, LLC.
Serious - Use AlternativePotential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

ivacaftor oral and dexamethasone sodium phosphate iv

ivacaftor oral increases levels of dexamethasone sodium phosphate iv by affects how the drug is eliminated from the body (via what is known as the P-glycoprotein [MDR1] transporter). Ivacaftor increases blood levels of the other drug.

Patient Drug Interactions Source: RxList
© 2014 RxList, Inc.
Serious - Use AlternativePossible serious or life-threatening interaction. Monitor closely. Use alternatives if available.

ivacaftor oral and dexamethasone sodium phosphate iv

ivacaftor oral increases levels of dexamethasone sodium phosphate iv by P-glycoprotein (MDR1) efflux transporter. Ivacaftor and its M1 metabolite has the potential to inhibit P-gp, may significantly increase systemic exposure to P-gp substrates

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2014 WebMD, LLC.

Check for more interactions with the Drug Interaction Checker

Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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