Drug interactions with digoxin oral and methotrexate sodium oral

digoxin oral brand names and other generic formulations include:

Cardoxin Oral, Digitek Oral, Lanoxicaps Oral, Lanoxin Oral

All generic drug interactions for digoxin oral (lists will include brand and generic names):

methotrexate sodium oral brand names and other generic formulations include:

Methotrexate (Anti-Rheumatic) Oral, Rheumatrex Oral, Trexall Oral

All generic drug interactions for methotrexate sodium oral (lists will include brand and generic names):
Significant - Monitor CloselyPotential for interaction

digoxin oral and methotrexate sodium oral

digoxin oral decreases levels of methotrexate sodium oral by reducing drug absorption from the stomach and intestine into the body when taken by mouth. Blood levels of digoxin may decrease leading to reduced effect.

Patient Drug Interactions Source: RxList
© 2014 RxList, Inc.
Significant - Monitor CloselyPotential for interaction, monitor.

digoxin oral and methotrexate sodium oral

digoxin oral decreases levels of methotrexate sodium oral by inhibition of GI absorption. Applies only to oral form of both agents. Serum levels of digoxin may be reduced and actions may be decreased. Monitor patient for signs of reduction in pharmacologic effect of digoxin and increase digoxin dose if necessary. Serum level monitoring may facilitate tailoring dosage.

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2014 WebMD, LLC.
Significant - Monitor CloselyPotential for interaction

methotrexate sodium oral and digoxin oral

methotrexate sodium oral decreases levels of digoxin oral by reducing drug absorption from the stomach and intestine into the body when taken by mouth. Blood levels of digoxin may decrease leading to reduced effect.

Patient Drug Interactions Source: RxList
© 2014 RxList, Inc.
Significant - Monitor CloselyPotential for interaction, monitor.

methotrexate sodium oral and digoxin oral

methotrexate sodium oral decreases levels of digoxin oral by inhibition of GI absorption. Applies only to oral form of both agents. Serum levels of digoxin may be reduced and actions may be decreased. Monitor patient for signs of reduction in pharmacologic effect of digoxin and increase digoxin dose if necessary. Serum level monitoring may facilitate tailoring dosage.

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2014 WebMD, LLC.

Check for more interactions with the Drug Interaction Checker

Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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