Drug interactions with erlotinib oral and phenytoin oral

erlotinib oral brand names and other generic formulations include:

Tarceva Oral

All generic drug interactions for erlotinib oral (lists will include brand and generic names):

phenytoin oral brand names and other generic formulations include:

Dilantin Infatabs Oral, Dilantin-125 Oral, Lorantoin Oral

All generic drug interactions for phenytoin oral (lists will include brand and generic names):
Significant - Monitor CloselySignificant interaction possible (monitoring by your doctor required)

erlotinib oral and phenytoin oral

erlotinib oral will decrease the level or effect of phenytoin oral by affects how the drug is eliminated from the body (via what is known as the P-glycoprotein [MDR1] transporter).

Patient Drug Interactions Source: RxList
© 2014 RxList, Inc.
Significant - Monitor CloselySignificant interaction possible, monitor closely.

erlotinib oral and phenytoin oral

erlotinib oral will decrease the level or effect of phenytoin oral by P-glycoprotein (MDR1) efflux transporter.

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2014 WebMD, LLC.
Significant - Monitor CloselySignificant interaction possible (monitoring by your doctor required)

phenytoin oral and erlotinib oral

phenytoin oral will decrease the level or effect of erlotinib oral by altering drug metabolism. Avoid taking these drugs together because blood levels of erlotinib are reduced.

Patient Drug Interactions Source: RxList
© 2014 RxList, Inc.
Significant - Monitor CloselySignificant interaction possible, monitor closely.

phenytoin oral and erlotinib oral

phenytoin oral will decrease the level or effect of erlotinib oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid concomitant use because there is a potential for decreased erlotinib exposure and efficacy. However, if concomitant use is clinically warranted, consider an increase in erlotinib dose as tolerated at 2 week intervals and monitor patient's safety. If

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2014 WebMD, LLC.

Check for more interactions with the Drug Interaction Checker

Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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