Drug interactions with ivacaftor oral and paclitaxel iv

ivacaftor oral brand names and other generic formulations include:

Kalydeco Oral

All generic drug interactions for ivacaftor oral (lists will include brand and generic names):

paclitaxel iv brand names and other generic formulations include:

Onxol IV, Taxol IV

All generic drug interactions for paclitaxel iv (lists will include brand and generic names):
Serious - Use AlternativePotential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

ivacaftor oral and paclitaxel iv

ivacaftor oral increases levels of paclitaxel iv by affects how the drug is eliminated from the body (via what is known as the P-glycoprotein [MDR1] transporter). Ivacaftor increases blood levels of the other drug.

Patient Drug Interactions Source: RxList
© 2014 RxList, Inc.
Serious - Use AlternativePossible serious or life-threatening interaction. Monitor closely. Use alternatives if available.

ivacaftor oral and paclitaxel iv

ivacaftor oral increases levels of paclitaxel iv by P-glycoprotein (MDR1) efflux transporter. Ivacaftor and its M1 metabolite has the potential to inhibit P-gp, may significantly increase systemic exposure to P-gp substrates

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2014 WebMD, LLC.
Serious - Use AlternativePotential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

paclitaxel iv and ivacaftor oral

paclitaxel iv increases levels of ivacaftor oral by altering drug metabolism. Levels of both drugs may increase.

Patient Drug Interactions Source: RxList
© 2014 RxList, Inc.
Serious - Use AlternativePossible serious or life-threatening interaction. Monitor closely. Use alternatives if available.

paclitaxel iv and ivacaftor oral

paclitaxel iv increases levels of ivacaftor oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Ivacaftor and its M1 metabolite has the potential to inhibit CYP3A4, may significantly increase systemic exposure to 3A4 substrates

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2014 WebMD, LLC.

Check for more interactions with the Drug Interaction Checker

Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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